人食管鳞癌组织中RhoC和Ki-67的表达及意义  

Expression and clinical significance of RhoC and Ki-67 in human esophageal squamous cell carcinoma tissues

作　　者：林尤恩[1] 倪仰鹏[1] 王晓芬[1] 王春冰[1] 

机构地区：[1]揭阳市人民医院,广东揭阳522000

出　　处：《中国病理生理杂志》2013年第6期1133-1135,1141,共4页Chinese Journal of Pathophysiology

摘　　要：目的:检测人食管鳞癌组织中RhoC和Ki-67的表达,探讨它们在食管鳞癌发生发展中的作用及相关性。方法:采用免疫组织化学方法(二步法),检测分析52例人食管鳞癌组织中RhoC和Ki-67蛋白的表达情况及其与患者临床病理特征的关系。结果:(1)食管鳞癌组织RhoC蛋白的阳性表达率为61.5%(32/52),相应癌旁组织RhoC阳性表达率为29.7%(11/37),差异显著(P<0.05)。(2)RhoC表达与食管鳞癌临床TNM分期和淋巴结转移密切相关,TNMⅢ期食管鳞癌组织中RhoC阳性表达率为78.3%(18/23),显著高于TNMⅠ～Ⅱ期的48.3%(14/29)(P<0.05);伴有淋巴结转移的食管鳞癌组织中RhoC阳性表达率为81.8%(18/22),显著高于无淋巴结转移的46.7%(14/30)(P<0.05)。(3)食管鳞癌组织中,RhoC与Ki-67的表达呈显著正相关(r=0.322,P<0.05),均呈升高趋势。结论:RhoC的高表达与食管鳞癌的分期、淋巴结转移及细胞增殖密切相关。RhoC可成为食管鳞癌早期诊断和判断预后的辅助指标。AIM： To investigate the expression and significance of RhoC and Ki-67 in human esophageal squa- mous cell carcinoma （ESCC） tissues. METHODS： The expression of RhoC and Ki-67 was detected in 52 specimens of ESCC by the method of immunohistochemistry. The clinicopathological features were also analyzed. RESULTS： The ex- pression of RhoC was detected in 32 of the total 52 （61.5%） cases of human ESCC tissues, significantly higher than that in the adjacent histologically normal epithelium, which was only in 11 of 37 cases （29.7% , P 〈 0.05 ）. RhoC expression was closely correlated with clinical tumor-node-metastasis （TNM） stage （ P 〈 0. 05） and lymph node metastasis （ P 〈 0. 05 ） in ESCC. The over-expression of RhoC was positively correlated with Ki-67 in ESCC （ r = 0. 322, P 〈 0. 05 ）. CONCLUSION： The over-expression of RhoC protein significantly correlates with advanced TNM stage, lymph node me- tastasis and cell proliferation ability of ESCC. Therefore, RhoC may be a new auxiliary parameter for early diagnosis and prognostic evaluation of ESCC.

关 键 词：食管肿瘤 RHOC蛋白 KI-67抗原 

分 类 号：R363[医药卫生—病理学]