人脐带间充质干细胞治疗严重失代偿肝硬化伴皮肤广泛撕裂伤1例  

Human umbilical cord mesenchymal stem cells in patients with decompensated cirrhosis complicated with wide-ranging injury of skin: a case and review

作　　者：臧祖胜[1] 傅青春[1] 陈今伟[1] 李震宇[1] 李莉[1] 金银鹏[1] 周丰[1] 施莉琴[1] 陈成伟[1] 王晓今[1] 

机构地区：[1]解放军第八五医院,南京军区上海肝病研究中心,上海200235

出　　处：《肝脏》2013年第5期303-305,共3页Chinese Hepatology

摘　　要：目的对严重肝硬化失代偿期伴皮肤广泛撕裂伤患者以人脐带间充质干细胞进行试验性治疗并观察其疗效。方法以人脐带间充质干细胞多点、多次注射于皮肤创面周围,同时联合静脉输注治疗。结果人脐带间充质干细胞治疗后10d,患者皮肤创面周围皮肤水肿消退,渗出减少,肉芽组织及皮岛生长明显,治疗后23d创面完全愈合;患者CTP及MELD评分分别由入院时的10分及8.31分降至皮肤创面愈合时的7分及5.03分。结论采用局部注射联合全身输注人脐带间充质干细胞治疗肝硬化失代偿合并皮肤损伤,可明显加快创面愈合,促进大面积破溃皮肤的再生。Objective To observe the efficacy of human umbilical cord mesenchymal stem cells in a patient with decompensated cirrhosis complicated with wide-ranging injury of skin. Methods Human umbilical cord mesenchymal stem cells were injected into the skin around the lesions on multiple pornts and multiplc times and simultaneously intravenous infusion of the stem cells was carried out. Results The edema around the lesions subsided and the exudation reduced on 10^th day of the human umbilical cord mesenchymal stem cells therapy. There was a significant growth of granulation tissue and the skin island on the wound. The skin lesions was completely healed on 23^th day of the therapy. CTP and MELD scores reduced from 10 and 8.31 to 7 and 5.03 respectively. Conclusion The local injection combined with the intravenous infusion of human umbilical cord mesenchymal stem cells can accelerate the wound healing and promote the skin regrowth significantly in decompensated cirrhosis patients with wide-ranging injury of skin.

关 键 词：人脐带间充质干细胞 肝硬化 皮肤损伤 

分 类 号：R575.2[医药卫生—消化系统]