牙龈卟啉单胞菌的荚膜及其免疫原性  

The capsule of Porphyromonas gingivalis and its immunogenicity

作　　者：王依玮(综述)[1] 刘大力[1] 束蓉(审校)[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院牙周科,上海市口腔医学重点实验室,上海200011

出　　处：《国际口腔医学杂志》2013年第4期540-543,共4页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30901672);上海市口腔基础医学重点学科建设基金资助项目(S30206-fzd03)

摘　　要：牙龈卟啉单胞菌是牙周主要致病菌之一,为革兰阴性专性厌氧无芽孢球杆菌。牙龈卟啉单胞菌的多种菌体成分可诱导宿主的免疫炎症反应,引起牙周组织损伤而致牙周组织疾病。牙龈卟啉单胞菌合成并分泌的多糖聚合物包绕细菌的细胞壁,构成荚膜结构。该结构参与牙龈卟啉单胞菌诱导的宿主免疫炎症反应,为该菌的主要毒力因子之一。根据荚膜多糖K抗原的差异,可将牙龈卟啉单胞菌荚膜分为K1～K6六种血清型。本文就牙龈卟啉单胞菌荚膜结构及其免疫原性等研究进展作一综述。Porphyromonas gingivalis （P.gingivalis）, the principal organism associated with periodontal disease, is a Gram-negative, anaerobic and nonmotile bacterium. It has been reported that many bacterial structures of P.gingivalis can induce human immune response which leads to tissue damage and establishment of periodontal disease. P.gingivalis can synthesize and secret polysaccharide which encapsulates bacterial cell wall to form a capsular structure. It has been confirmed that the capsular polysaccharide （CPS） involves in P.gingivalis-induced host immune response to serve as an important virulence factor of this pathogen. According to the K-antigen of CPS, P. gingivalis can be devided into six serotypes, K1-K6. This review focuses on CPS structure and immunogenicity of P.gingivalis.

关 键 词：牙龈卟啉单胞菌 荚膜多糖 血清型 免疫原性 

分 类 号：R780.2[医药卫生—口腔医学]