中国狂犬病病毒的分群和进化特征  

Grouping and evolution characteristics of rabies virus in China

作　　者：陶晓燕[1] 李浩[1] 焦文涛[1] 唐青[1] 梁国栋[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,卫生部医学病毒和病毒病重点实验室,北京102206

出　　处：《疾病监测》2013年第5期340-343,共4页Disease Surveillance

基　　金：国家科技重大专项(No.2012ZX10004-215)~~

摘　　要：目的为全面掌握我国狂犬病病毒的遗传进化特征和分群特点。方法对GenBank上具有明确时间、地域及宿主信息的中国街毒株G基因全序进行汇总,并结合本实验室获得的中国流行株G序列,利用BEAST软件,进行系统的时间进化分析。结果中国狂犬病流行株G基因的时间进化分析显示,我国流行株明显分为6群:ChinaⅠ群是我国的绝对优势群,数量占总数的80%以上,分布于19个省(自治区、直辖市);ChinaⅡ群,包括来自7个省(自治区、直辖市)的49个流行株;ChinaⅢ、Ⅳ、Ⅴ和Ⅵ群数量较少,分布地域也较为局限。中国流行株的最近共同祖先(TMRCA)可追溯至392年前。结论 ChinaⅠ群是我国目前优势毒株群,同时应注意防范ChinaⅡ群和ChinaⅣ群野生动物来源的狂犬病流行。Objective To fully understand the grouping and evolution characteristics of rabies virus in China.MethodsThe phylogenetic analysis of rabies virus in China was conducted by using G gene complete sequences of China rabies street strains with clear background information obtained from GenBank and the G gene sequences of China rabies circulating strains collected by our laboratory with BEAST software.Results The analysis indicated that China rabies street strains can be classified as 6 groups: Group China Ⅰ is predominant,accounting for >80%,and circulates in 19 provinces.Group China Ⅱ,including 49 strains,circulates in 7 provinces.Group China Ⅲ,China Ⅳ,China Ⅴ and China Ⅵ include a few strains and circulate in limited areas.It is estimated that TMRCA,the common ancestor of China rabies circulating strains,was detected about 392 years ago.Conclusion Rabies virus group China Ⅰ is predominant in China,but the prevention and control of rabies caused by China Ⅱ and China Ⅵ viruses,related with wild animal rabies,should not be neglected.

关 键 词：狂犬病 狂犬病病毒 进化 流行 

分 类 号：S852.65[农业科学—基础兽医学]