我国96例散发型克雅氏病患者随访调查及生存分析  

Follow up of 96 sporadic Creutzfeldt-Jakob disease cases in China

作　　者：王吉春[1] 陈操[2] 石琦[2] 周伟[2] 张晓美[2] 董小平[2] 

机构地区：[1]中国疾病预防控制中心科学技术处,北京102206 [2]中国疾病预防控制中心病毒病预防控制所朊病毒病室

出　　处：《疾病监测》2013年第5期344-346,共3页Disease Surveillance

基　　金：国家科技重大专项(No.2011ZX10004-101);传染病预防控制国家重点实验室自主研究面上课题(No.2012SKLID102;2011SKLID211);中国疾病预防控制中心青年科研基金(No.2012A102)~~

摘　　要：目的了解中国散发型克雅氏病(sporadic Creutzfeldt-Jakob disease,sCJD)患者生存情况及生存时间。方法选择2008年1月1日至2011年12月31日期间经我国CJD监测网络诊断的96例sCJD患者,对其家属进行电话随访,获得生存情况及死亡时间。同时从全国死因监测系统中补充患者相关资料,分析可能影响生存时间的因素。结果 96例sCJD患者全部在2年内死亡,其中位生存时间为6.1个月,生存时间短于3、6、12、24个月的累计百分比分别为15.6%、42.7%、74.0%和100%;首发症状、出现典型临床表现的数量对患者生存时间没有明显影响。结论中国sCJD患者的中位生存时间为6.1个月,整体生存时间<2年。Objective To evaluate the survive of sporadic Creutzfeldt-Jakob disease(sCJD) cases in China.MethodsAll 96 sCJD patients reported by national CJD surveillance network between 1 January 2008 and 31 December 2011 were enrolled in this study.The follow up of their survival status/length were made by telephone call to the patients' family members.The epidemiological and clinical information of the patients were obtained from CJD surveillance network and the association between clinical manifestations and survival length were analyzed.Results All the 96 sCJD patients died within 2 years after onset.The median of the survival length was 6.1 months.The cumulative proportions of the survival length less than 3,6,12 and 24 months were 15.6%,42.7%,74.0% and 100%,respectively.The initial manifestation and the frequency of typical clinical symptom had no significant effect on the patients' survival length.Conclusion All the sCJD patients in China died within 2 years after onset,the median of the survival length was 6.1 months.The general socio-demographic characteristics and clinical features of the patients did not influence the survival length of the patients.

关 键 词：监测 散发型克雅氏病 随访 生存分析 

分 类 号：R742.9[医药卫生—神经病学与精神病学]