巨噬细胞炎症蛋白-1α和骨硬化蛋白在多发性骨髓瘤中的表达及临床意义  

Study on the expression of macrophage inflammatory protein 1-α(MIP-1α) and Sclerostin in the supernate of bone marrow in patients with multiple myeloma

作　　者：王晓桃[1] 唐荣芳[1] 刘玲[1] 何玉婵[1] 覃泱[1] 

机构地区：[1]桂林医学院附属医院血液科,广西桂林541001

出　　处：《中国现代医学杂志》2013年第8期62-65,共4页China Journal of Modern Medicine

基　　金：广西自然科学基金(No:2012GXNSFAA053112);桂林市科技攻关项目(No:Z20110119-1-12)

摘　　要：目的研究多发性骨髓瘤(MM)患者骨髓上清液巨噬细胞炎症蛋白-1α(MIP-1α)和骨硬化蛋白(Sclerostin)的表达水平,探讨其在MM发病中的临床意义。方法采用酶链免疫法定量检测MIP-1α和Sclerostin的水平。结果 MM组中MIP-1α([152.44±96.29)pg/mL]和Sclerostin([0.53±0.24)pg/mL]水平明显高于对照者,两者比较差异有统计学意义(t值分别为5.69和4.70,P值分别为0.00和0.001);Ⅲ期MM患者的MIP-1α([172.91±102.41)pg/mL]和Sclerostin([0.61±0.22)pg/mL]的水平明显高于Ⅱ期患者(t值分别为3.70和2.87,P值分别为0.001和0.007);3级MBD患者的MIP-1α([191.41±110.82)pg/mL]和Sclerostin([0.68±0.19)pg/mL]明显高于非3级MBD患者(t值分别为3.01和5.69,P值分别为0.005和0.00);MM组中MIP-1α和Sclerostin表达呈正相关关系(r=0.498,P=0.002)。结论大部分MM患者骨髓MIP-1α和Sclerostin水平增高,其水平可反映体内瘤负荷及骨质破坏的程度,且两者具有明显相关性,联合检测可作为评估MM患者病变严重程度的一项指标。[Objectives] To investigate the expression of macrophage inflammatory protein 1-α （MIP-1α） and Sclerostin in patients with a multiple myeloma （MM）, and clarify their clinical signification. [Methods] MIP-1α and Sclerostin ware quantified using ELISA. [Results] The BM plasma levels of MIP-1α （152.44 ± 96.29） pg/mL and Sclerostin （0.53 ± 0.24） pg/mL in patients at diagnosis were significantly higher than in the controls （t=5.69, 4.70; P=0.00, 0.001〈0.01）. The levels of MIP-loL （172.91 ± 102.41） pg/mL and Sclerostin （0.61 ：t： 0.22） pg/mL in patients with ][[ stages of International Staging System for multiple myeloma were sig- nificantly higher than in patients with ]Istages （t=3.70, 2.87; P=0.001, 0.007）. The levels of MIP-loL （191.41 ± 110.82） pg/mL and Sclerostin （0.68 ± 0.19） pg/mL in patients with 3 grade of myeloma bone diseases were significantly higher than that in patients with non-3 grade （t =3.01, 5.69; P=0.005, 0.00）. There were positive relation between the expressions of MIP-1α and Sclerostin （r=0.498, P=0.002）. [Conclusion] Most of pa- tients with MM have increased the levels of MIP-α and Sclerostin in marrow plasm. The levels of them may reflect the myeloma burden and bone destruction, and there is a significant relation between them.

关 键 词：巨噬细胞炎症蛋白-1Α 骨硬化蛋白 多发性骨髓瘤 骨髓瘤骨病 

分 类 号：R733.3[医药卫生—肿瘤]