基质金属蛋白酶-1基因多态性与动脉粥样硬化性脑梗死相关性研究  

Relationship between matrix metalloproteinase-1 gene polymorphism and atherosclerotic cerebral infarction

作　　者：张晋霞[1] 张志勇[2] 刘斌[1] 史富华[3] 李绍彩[4] 张文彦[1] 张蕊[1] 

机构地区：[1]河北联合大学附属医院神经内科,河北唐山063000 [2]河北联合大学附属医院神经外科,河北唐山063000 [3]遵化市人民医院神经内科,河北遵化064200 [4]遵化市人民医院心内科,河北遵化064200

出　　处：《检验医学与临床》2013年第12期1491-1492,共2页Laboratory Medicine and Clinic

基　　金：河北省卫生厅医学重点课题(项目编号:20110169)

摘　　要：目的研究基质金属蛋白酶-1(MMP-1)基因多态性与动脉粥样硬化性脑梗死(ACI)的相关性。方法检测95例ACI患者(不稳定斑块组51例、稳定斑块组44例)和58例体检健康者外周血MMP-l水平及MMP-l基因启动子区上游-1 607bp处1G或2G单核苷酸多态性,比较不同MMP-l基因型频率和外周血MMP-l水平。结果不稳定斑块组2G/2G基因型频率和2G等位基因频率显著高于稳定斑块组,二者2G/2G基因型频率与2G等位基因频率均显著高于对照组,且不稳定斑块组和稳定斑块组外周血MMP-l水平均高于对照组(P<0.05)。结论 MMP-1基因多态性和外周血MMP-1水平均与ACI具有相关性。Objective To study the relevance of matrix metalloproteinase-1 （MMP-1） gene polymorphism and atherosclerotic cerebral infarction （ACI）. Methods 95 patients with ACI, including 51 cases for unstable plaques group and 44 cases for stable plaques group,and 58 cases of healthy subjects （control group） were detected for 1G or 2G single nucleotide polymorphisms at -1 607 bp in upstream of MMP-1 gene promoter region and peripheral blood level of MMP-1. All results were compared between the three groups. Results The 2G/2G genotype and 2G allele frequency in unstable plaque group were significantly higher than those in stable plaque group, those in the two pa- tient groups were significantly higher than in control group,and MMP-1 levels in the two patient groups were higher than that in control group （P〈0.05）. Conclusion MMP-1 gene polymorphism and blood MMP-1 level might be as- sociated with the incidence of ACI.

关 键 词：动脉粥样硬化 基质金属蛋白酶-1 基因多态性 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]