DNA倍体分析筛查宫颈及癌前病变的意义  

The clinical value of DNA ploidy pattern analysis in screening for cervical cancer

作　　者：刘贵珍[1] 杨权[1] 广圣芳[1] 

机构地区：[1]安徽医科大学附属六安医院,安徽237005

出　　处：《安徽卫生职业技术学院学报》2013年第3期82-83,共2页Journal of Anhui Health Vocational & Technical College

摘　　要：目的：探讨细胞DNA倍体分析在宫颈筛查中的应用.方法：宫颈糜烂患者500例,由妇科医生留取标本,用麦克奥迪（厦门）全自动细胞图像分析系统对标本行Feulgen染色后进行DNA定量分析系统自动扫描分析;对有异常者进一步作阴道镜检查或活检确诊.结果：500例中发现有异常者60例,其中1~2个异倍体细胞的36例,≥3个异倍体细胞的24例,病理检查结果显示：正常者4例,宫颈炎19例,宫颈上皮内瘤样病变CINⅠ15例,CINⅡ8例,CINⅢ 11例,宫颈癌3例,DNA倍体分析系统与病理诊断符合率为93.3%（56/60）.结论：全自动DNA倍体分析系统可以作为辅助方法,对宫颈及其癌前病变早期诊断具有重要的参考价值.Objective：To observe the clinical value of DNA ploidy pattern analysis in screening for cervical cancer. Methods：500 samples from cervical erosion patients were analysed by DNA ploidy pattern analysis system. Furthermore, the abnormal of all were confirmed by histopathology.Results：60 abnormal cases were found by DNA ploidy pattern analysis system. Of these, there was one or two heteroploid cells in 36 cases and more than 3 heteroploid cells in 24. The results of histopathology diagnosis shows 19 cases of Cervicitis, 15 of cervical intraepithelial neoplasia I （CIN I ）, 8 of CIN I], 11 of CIN IU, 3 of cervical cancer and 4 of normal among 60 abnormal cases. The diagnose accordance rate was 93.3% between DNA ploidy pattern analysis system and histopathology diagnosis. Conclusions：As a sumplemetary method, DNA ploidy pattern analysis system is of great value for early diagnosis of cervical cancer.

关 键 词：全自动细胞DNA倍体分析系统 宫颈癌 筛查 

分 类 号：R737.33[医药卫生—肿瘤]