炎症--肿瘤恶性演进的推手  

Inflammation:A promoter in malignant progression of tumor

作　　者：郭靓[1] 钱露[1] 郭宁[1] 

机构地区：[1]军事医学科学院基础医学研究所病理生理学研究室,北京100850

出　　处：《中国肿瘤生物治疗杂志》2013年第3期259-265,共7页Chinese Journal of Cancer Biotherapy

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2010CB911904);国家自然科学基金资助项目(No.31271440,No.81272232,No.30972690)~~

摘　　要：越来越多的证据表明,炎性微环境在肿瘤的发生、发展中发挥着重要的促进作用,炎性因子介导的信号通路参与了肿瘤细胞的恶性演进。细胞上皮-间质转型(epithelial-mesenchymal transition,EMT)是肿瘤恶性演进过程中的关键机制,炎性细胞因子(白细胞介素、TNF-α、TGF-β等)、EMT的关键转录因子[锌指E盒结合同源盒蛋白(zinc finger E-box-binding homeobox,ZEB)、Snail和Twist等]及某些miRNA(let-7、miR-200等)共同构成复杂的调控网络,调控肿瘤细胞的表型转化、药物抗性的产生、肿瘤干细胞(cancer stem cell,CSC)的增殖及自我更新。本文将重点讨论炎症及相关信号通路在肿瘤发生、发展以及CSC形成过程中的调控机制。Increasing evidence indicated that tumor inflammatory microenviroment plays an important role in cancer initiation and development.The signaling pathways mediated by inflammatory cytokines participate in malignant transformation of tumor cells.Epithelial-mesenchymal transition（EMT） is a critical mechanism underlying transformation of tumor cells.A network composed by inflammatory cytokines（interleukin,TNF-α and TGF-β）,key transcription factors of EMT,including zinc finger E-box-binding homeobox（ZEB）,Snail and Twist,and some miRNAs（let-7 and miR-200） regulates malignant transformation of tumor,generation of drug resistance and the proliferation and the self-renewal of cancer stem cell（CSC）.This article reviews the recent studies on the molecular mechanisms,by which inflammation and related signaling pathways regulate tumor initiation,development and CSC formation.

关 键 词：肿瘤 炎症 肿瘤干细胞 细胞上皮-间质转型 STAT3 NF-ΚB 

分 类 号：R730.2[医药卫生—肿瘤]