肝内NK细胞抗肿瘤机制的研究进展  

Antitumor mechanism of intrahepatic NK cells

作　　者：张金岭[1] 殷忠美[1] 李宝生[2] 

机构地区：[1]山东大学附属临沂市人民医院肿瘤科,山东临沂276000 [2]山东省肿瘤医院放疗六科,山东济南250117

出　　处：《中华肿瘤防治杂志》2013年第13期1038-1042,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:总结近几年来关于肝内NK细胞抗肿瘤机制方面的研究进展。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"肝内NK细胞、抗肿瘤、活化和受体"为关键词,检索2008-01-01-2012-05-01的相关文献,共检索到英文文献1 022篇和中文文献822篇。纳入标准:1)肝内NK细胞的特点;2)NK细胞的活化;3)肝内NK细胞抗肿瘤的机制;4)肝脏微环境对NK细胞的影响。根据纳入标准符合分析文献37篇。结果:浸润肝内的NK细胞在数量和功能方面有一定的特点,有独特的抗肿瘤活性,不但可以直接攻击肿瘤细胞,而且在肿瘤识别和抗原提成方面扮演重要角色,是对肿瘤细胞进行免疫耐受或者免疫攻击选择的的关键识别点之一,同时对机体免疫状态的平衡也起重要的调节作用。进一步探索肝内NK细胞的抗肿瘤机制,对了解肿瘤患者病情预后和临床抗肿瘤治疗有重要作用。结论:肝内的NK细胞有独特的抗肿瘤活性,因而深入研究肝内NK细胞的抗肿瘤机制可以为临床抗肿瘤研究提供新思路。OBJECTIVE：To sum up the progress in the research of antitumor mechanism of intrahepatic NK cells re cent years. METHODS：Totally 1 022 English articles and 822 Chinese papers were searched by ＂Intrahepatic NK cells,an- titumor,avtivation,receptors＂ as key words in PUBMED and CNKI database from 2008-01-01- 2012-05-01. Totally 37 papers were reselected and analyzed according to the inclusion criteria as follows： 1） the character of Intrahepatic NK cells;2） the activation of NK ceil;3） the antitumor mechanism of intrahepatie NK cells. RESULTS： Because of the special characteristics in quantity and functional activity,intrahepatic NK cells plays a unique antitumor activity and function,and plays an important role in regulating the immune system. Not only can directly attack the tumor cells,but also have effect on tumor recognition and antigen presenting. Intrahepatic NK cell aslo is the one of key identification points of the immune system choose to attack the tumor cells or not. NK cells play an important role in the understanding of prognosis and clini- cal antitumor therapy for cancer patients. CONCLUSION： Because the intrahepatic NK cells have special antitumor effects, the investigation of the antitumor mechanism of intrahepatic NK cells provide new ideas for antitumor studying.

关 键 词：肿瘤 NK细胞 机制 受体 综述文献 

分 类 号：R735.7[医药卫生—肿瘤]