鼻多形性低度恶性腺癌临床病理观察  被引量:1

Clinical and pathologic characteristics of polymorphous low-grade adenocarcinoma in the nasal cavity

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作  者:岳颖[1] 李德昌[1] 任力[1] 朱建平[1] 

机构地区:[1]空军总医院病理科,北京100142

出  处:《现代肿瘤医学》2013年第7期1485-1487,共3页Journal of Modern Oncology

摘  要:目的:探讨鼻腔多形性低度恶性腺癌(PLGA)的临床病理特点和鉴别诊断。方法:回顾分析4例鼻部PLGA的临床病理和免疫表型特点,并复习文献。结果:4例PLGA患者均为中老年,男女各半。受累部位单侧鼻腔2例,双侧鼻腔2例。临床主要表现为鼻塞和鼻出血,或伴流涕和嗅觉减退。光镜下肿瘤呈现细胞形态单一,组织结构多样的特点。免疫组织化学染色显示肿瘤细胞CK(AE1/AE3)、S-100、SMA、Vim阳性,部分病例EMA和CEA阳性,而p63和GFAP阴性。结论:鼻腔多形性低度恶性腺癌非常罕见,具有和小涎腺多形性低度恶性腺癌相似的组织形态学特点,与腺样囊性癌的鉴别非常重要,免疫组化Vim检测有助于二者的鉴别。Objective:To research the clinical pathological features and differential diagnosis of polymorphous low-grade adenocarcinoma(PLGA) in the nasal cavity.Methods:The clinical pathological features and immunohistochemical results were analyzed in 4 cases of PLGA in the nasal cavity,with review of the related literatures.Results:All 4 patients were middle-aged,and the male-female ratio was 1∶1.The sites of occurrence included unilateral nasal cavity(2 cases) and bilateral nasal cavity(2 cases).Major clinical presentations included nasal blockage and epistaxis,(or) with the following symptoms:runny nose and hyposmia.Microscopically,the tumor had uniform cytological and variable growth patterns.Immunohistochemically,these cells were positive for CK(AE1/AE3),S-100,SMA and Vim;partly positive for EMA and CEA;negative for p63 and GFAP.Conclusion:PLGA of nasal cavity is rare,with similar histopathological features to PLGA in minor salivary glands.A correct differential diagnosis is particularly important and vimentin may be useful marker allowing distinction between PLGA and adenoid cystic carcinoma(ACC).

关 键 词:鼻腔 多形性低度恶性腺癌 诊断 

分 类 号:R739.61[医药卫生—肿瘤]

 

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