不同胃黏膜病变中iNOS表达与Hp的关系  

The relationship between iNOS expression and Helicobacter pylori infection in gastric cancer and precancerous lesion

作　　者：雷琳[1] 黄亚平[1] 龚文容[1] 朱庆茹[1] 

机构地区：[1]襄阳市中心医院肿瘤科,湖北襄阳441000

出　　处：《现代肿瘤医学》2013年第7期1558-1561,共4页Journal of Modern Oncology

基　　金：湖北省自然科学基金重点项目(编号:2011CDA065)

摘　　要：目的:检测诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)在胃癌前病变及胃癌的表达,及其与幽门螺杆菌(Helicobacter pylori,Hp)感染的相关性,探讨Hp感染与胃癌发生的关系。方法:收集慢性浅表性胃炎(chronic superficial gastritis,CSG),慢性萎缩性胃炎伴肠上皮化生(Intestinal metaplasia,IM),慢性萎缩性胃炎伴上皮内瘤变(Intraepithelial neoplasia,IN)各30例,胃癌(gastric cancer,GC)40例。采用SP免疫组化法检测iNOS蛋白的表达,warthin-starry银染法检测胃黏膜Hp感染。结果:CSG、IM、IN、GC组织中iN-OS表达呈逐渐增强趋势,差异具有显著性(P<0.05)。结论:CSG、IM、IN、GC组织中Hp感染的胃黏膜组织中,iNOS的表达高于无Hp感染的患者。Objeetive：To explore the relationship of inducible nitric oxide synthase and Helicobacter pylori（Hp） infection in the pathogenesis of gastric cancer.Methods：The expression of iNOS was determined by immunohistochemical method in 130 gastric specimens including 30 cases of chronic superficial gastritis,30 cases of intestinal metaplasia,30 cases of intraepithelial neoplasia and 40 cases of gastric carcinomas.Results：In control group with chronic superficial gastritis,precancerous group,and gastri carcinoma group,the expression levels of iNOS had a increasing tendency（P0.05）.Conclusion：The expression of iNOS in Hp positive group is significantly higher than that in negative group.（P0.05）.

关 键 词：诱导型一氧化氮合酶 胃癌 幽门螺杆菌 表达 

分 类 号：R735.2[医药卫生—肿瘤]