88例涎腺粘液表皮样癌临床病理分析  

A clinicopathologic study of 88 cases of mucoepidermoid carcinoma of salivary glands

作　　者：史璐[1] 陈新明[2] 

机构地区：[1]郑州大学第四附属医院牙体牙髓科,河南郑州450000 [2]武汉大学口腔医学院病理科,湖北武汉430079

出　　处：《河南医学研究》2013年第3期321-324,共4页Henan Medical Research

基　　金：河南省科技厅科技攻关基金资助项目(112102310487);河南省政府决策研究招标项目(2011B765)

摘　　要：目的:采用Auclair量化分级系统对88例涎腺粘液表皮样癌进行临床病理分析,探讨组织学分级与肿瘤生物学行为间的关系。方法:根据本次实验的纳入排除标准选择涎腺粘液表皮样癌88例。采用Au-clair量化分级系统对本组病例行组织学分级,并行统计学分析。结果:低度恶性34例(38.6%),中度恶性(Ⅱ级)20例(22.7%),高度恶性(Ⅲ级)34例(38.6%)。Ⅲ级患者年龄长于Ⅰ级患者,[(43.7±17)vs(33.9±13.9)],P<0.05。Ⅰ级患者临床症状发生率(21%)低于Ⅱ级(50%)和Ⅲ级患者(76%)(P<0.5)。Ⅲ级病例的肿瘤直径[(3.8±1.4)cm]大于Ⅰ级[(2.9±1.8)cm]和Ⅱ级病例[(3.5±2.9)cm](P<0.05)。生存分析结果表明性别、临床分期、组织学分级与肿瘤复发显著相关(P<0.05)。结论:应用Auclair量化分级系统对涎腺粘液表皮样癌行组织学分级有助于判断肿瘤的预后。： Objective ： To evaluate the prognostic importance of Auclair＇ s quantitative grading system of mucoepidermoid carcinoma （MEC） of salivary gland. Methods ： Eighty-eight MEC of salivary glands were clinicopathologieally reviewed. Auelair＇ s quantitative grading system was used.Clinical and pathologic features were statistically analyzed. Results： Thirty-four cases （38.6%） were classified as low grade, 20（22.7% ） as intermediate grade and 34 （38.6%） as high-grade tumors. Patients with high grade tumors were older on average than those with low grade tumors [（43.7±17） vs （33.9±13.9）], P 〈0.05. The incidence of clinical symptom of low grade tumors （21%） was lower than that of intermediate （50%） and high grade tumors （76%） （P 〈 0.05）. Tumor sizes of high grade tumors （3.8 ±1.4） cm were larger than those of low （2.9±1.8） cm and intermediate grade tumors（3.5 ±2.9 ） cm （ P 〈 0. 05 ）. Survival analysis revealed that gender, clinical stage and pathologic grade were the major recurrence risk faetors（ P 〈0.05 ）. Conclusion ： In MEC of salivary glands, tumor grade , subdividing cases into low,intermediate and high grade by using the criteria delineated by Auclair, correlates well with prognosis.

关 键 词：涎腺 粘液表皮样癌 病理分级 预后 

分 类 号：R739.8[医药卫生—肿瘤]