皮下包埋两性霉素B对兔真菌性皮肤病治疗效果研究  

Study of Treatment effects of Subcutaneous Embedding Amphotericin to the Rabbit Fungal Skin Disease

作　　者：孟杨[1] 畅丽芳[1] 迟玉杨[2] 邵大富[2] 刘畅[2] 沈景林[2] 堵光莹[2] 王多伽[2] 彭易柱[2] 

机构地区：[1]吉林大学五星动物保健药厂,吉林长春130062 [2]吉林大学动物科学学院,吉林长春130062

出　　处：《吉林畜牧兽医》2013年第6期30-32,共3页Jilin Animal Husbandry and Veterinary Medicine

基　　金：国家科技部星火计划项目(2010GA690004);江苏省科技厅"苏北专项"项目(BN2008237);长春市科技局星火科技专家大院项目(2007NY03)

摘　　要：兔真菌性皮肤病是一类传染性极强的人畜共患接触性皮肤病。试验选取体重相近,已感染真菌性皮肤病的吉戎兔15只,分为3组,每组5只,试验组Ⅰ为对照组,注射生理盐水,组Ⅱ和组Ⅲ皮下分别包埋5mg和10mg的两性霉素颗粒剂。给药前和给药后第10天、第20天和第30天分别称重,并观察测定兔皮毛生长及秃斑恢复情况。结果表明,试验组兔增重均高于对照组,差异显著(<0.05),试验末期组Ⅱ和组Ⅲ秃斑恢复分别达95%和90%。因此,采用皮下包埋的给药方式有效地延长了两性霉素B的药效时间,可有效治愈兔真菌性皮肤病。Rabbit fungal skin disease is a kind of highly contagious and contact skin diseases between human beings and livestock. Positive test to select a weight similar to guitar rabbit farm breeding suspected rabbit fungal skin disease in clinical symptoms, examination, diagnosis rabbits infected with fungal skin disease Parasitology. Divided into three groups （n = 10）, sub-cage artificial feeding of 30 days, other things being equal. Group I for the control group, not administration. 5 mg ofAmphotericin B subcutaneous injection in Group Ⅱ,group of three subcutaneous injection of 10mg of Amphotericin B. Measure weight and mites in check. Prior to administration and 30 days after dosing, weighing 10 days 20 days 30 days before drug administration and mites inspection.The experimental group weight gain all higher than the other groups, have a certain effect ofAmphotericin B for the treatment of rabbit mites echinococcosis. And 5mg and 10 mg dose of the treatment of rabbit fungal skin disease effect was significantly higher than group Ⅰ. The results show that the effect of amphotericin B in the content of 5mg5 to the treatment of fimgal skin diseases of Rex Rabbit is significant. The subcutaneous embedding of mode of administration can effectively extend the effective time of amphotericin B.

关 键 词：皮下包埋 两性霉素B 吉戎兔 真菌性皮肤病 治疗效果 

分 类 号：S858.292[农业科学—临床兽医学]