厦门市海沧区结直肠癌筛查肿瘤阳性者术后近期疗效评价  

Short-term postoperative outcome of cancer positive patients during colorectal screening in Haicang district of Xiamen city

作　　者：颜松龄[1] 庄建民[1] 何洁[2] 李小华[2] 杨芳[3] 黄连江[4] 

机构地区：[1]福建省厦门市第二医院普通外科,厦门361021 [2]福建省厦门市第二医院内镜科,厦门361021 [3]福建省厦门市第二医院普内镜科,厦门361021 [4]福建省厦门市第二医院普检验科,厦门361021

出　　处：《福建医药杂志》2013年第3期8-11,共4页Fujian Medical Journal

基　　金：厦门市海沧区科技局科技计划项目(350205Z20084003)

摘　　要：目的通过分析厦门市海沧区结直肠癌筛查结果,评价肿瘤阳性者术后近期疗效。方法自2008年12月至2010年10月,结合问卷调查和粪便隐血试验方法,对该区4个行政村40～74岁常住居民进行初筛,高危人群接受全结肠镜检查。肿瘤阳性者(筛查组)手术后定期随访至少2年,并与同期住院的新发结直肠癌病例(非筛查组)比较1年及2年的总体生存率(OS)和无病生存率(DFS)。结果本次筛查检出结直肠癌14例,息肉201例;估算该地区结直肠癌粗发病率为51.4/10万。筛查组术后2年DFS优于非筛查组,差异有统计学意义(85.7%vs 57.1%,P<0.05);术后1年及2年OS、术后1年DSF亦优于非筛查组,但差异无统计学意义(100%vs 86.4%,92.6%vs 75.3%,92.6%vs 83.1%,P值均大于0.05)。结论结直肠癌筛查有利于结直肠癌的早诊早治及消除癌前病变,具有提高结直肠癌DSF、改善预后的优点。Objective To investigate the short-term postoperative outcome of cancer positive patients during colorectal cancer(CRC) screening in Haicang district of Xiamen city.Methods From Dec.2008 to Oct.2010,preliminary screening was carried out for the inhabitants from 44 to 74 years old in four countries of Haicang district combining questionaire and fecal occult blood test(FOBT).High risk people accepted complete colonoscopy.Cancer positive patients were followed-up up to two years postoperatively.One-year and two-year overall survival(OS) and disease free survival(DFS) were compared between the screening group and non-screening group(ie.the new CRC cases hospitalized during the counterpart period).Results There were 14 CRC and 201 polyps cases in screening group,the raw incidence of CRC in this district is 51.4/100 000.Two-year DFS in screening group was better than that in non-screening group(85.7% vs 57.1%,P<0.05).There were no statistically significant differences in one-year and two-year OS,and one-year DSF between the two groups(100% vs 86.4%,92.6% vs 75.3%,92.6% vs 83.1%,P>0.05).Conclusion CRC screening is beneficial to earlier detect and manage CRC and remove precancerous lesion,and has the advantages of improving disease free survival and prognosis.

关 键 词：结直肠癌 术后近期 阳性者 癌筛查 厦门市 疗效评价 肿瘤 全结肠镜检查 

分 类 号：R735.3[医药卫生—肿瘤]