丁螺环酮对精神分裂症患者认知功能的影响  

Effect of buspirone on cognitive function in stable schizophrenia patients

作　　者：叶萌[1] 苏德振[1] 周新芳[1] 徐晓津[1] 胡静[1] 房茂胜[1] 

机构地区：[1]武汉市精神卫生中心,湖北武汉430022

出　　处：《济宁医学院学报》2013年第3期195-197,共3页Journal of Jining Medical University

基　　金：湖北省卫生厅青年科技人才项目(QJX2012-36)

摘　　要：目的探讨丁螺环酮对稳定期精神分裂症患者认识功能的改善作用。方法 71例稳定期精神分裂症患者在原有治疗的基础上接受丁螺环酮30mg/d治疗,于基线、治疗后6周、3个月和6个月分别对受试患者经行DSST、WCST、BPRS评定。结果随访治疗6个月,研究组患者精神症状稳定,DSST高于基线水平(P<0.05),WCST持续应答两组间差异无显著性(P>0.05)。结论丁螺环酮能够改善正在维持AAPD治疗的精神分裂症患者的注意力。Objective To determine if the addition of buspirone would enhance cognitive function of schizophrenia treated with AAPD.Methods Seventy-one patients with schizophrenia,who had been treated with an AAPD for at least three months,were assigned to receive buspirone,30 mg/day.All other medications remained unchanged.Digital Symbol Substitution Test（DSST）,Wisconsin Card Sorting Test and Brief Psychiatric Rating Scale（BPRS）were assessed at baseline,6 weeks,3 months and 6 months.Results The patients remained stable.DSST of the sixth month was more higher than baseline（43.8±15.0）vs.（39.6±14.5）,P0.05）.There was no signifiant difference between two groups on WCST scores.Conclusion The results of this study showed a possible benefit of buspirone augmentation of AAPD to enhance attention.

关 键 词：丁螺环酮 非典型抗精神病药 认知功能 注意力 

分 类 号：R749.3[医药卫生—神经病学与精神病学]