IL-4抑制Lewis肺癌生长和转移的实验研究  

An experimental study on Inhibition of IL-4 on growth and metastasis of Lewis lung carcinoma

作　　者：夏东[1] 江曼[1] 胡雪峰 扬飞 

机构地区：[1]湖北医科大学基础医学院,武汉430071

出　　处：《氨基酸和生物资源》2000年第1期43-44,共2页Amino Acids & Biotic Resources

基　　金：湖北省自然科学基金!( 94 J0 80 );湖北省科委重点科研课题!( 962 P1 1 0 6)

摘　　要：探讨 IL -4对 Lewis肺癌生长和转移的抑制作用。将 Lewis肺癌细胞接种于 C57BL /6小鼠皮下。将 2 0只小鼠随机分为两组 ,接种后第 5天起分别给予生理盐水或 IL-4。第 1 8天处死动物 ,测两组肿瘤的平均体积 ,平均瘤重及肺转移灶。 、 组肿瘤的平均体积为 ( 2 .0 0 7± 0 .0 0 6) cm3 ,( 0 .4 0 4± 0 .0 1 0 ) cm3 ;平均瘤重为 ( 2 .83 3± 0 .0 74 ) g、( 0 .586± 0 .0 4 0 ) g,肺转移灶为 ( 5.50 0± 0 .92 6) ,( 3 .3 75± 1 .0 61 )。 组与 I组比差异有显著性 ( P<0 .0 5) ;平均潜伏期为 :8.3 0± 0 .4 9;1 0 .56± 0 .3 6。 IL-4能抑制 Lewis肺癌生长和转移。To investigate the inhibiting effects of IL-4 on Leuis lung cancer (LLC). Twenty mice trans planted with LLC Cells were randomized into two groups. From the 5th day, physiological saline and IL-4 were injected, respectively. On the 18th day, all the mice were killed. The volume,weight and lung metastasis counting of the tumors were detected. The tumor volume in group ⅠⅡ was (2.007±0.006)cm3, (0.404+0.010)cm3 respectively; the tumor weight of group ⅠⅡ was (2.833±0.074)g, (0.588±0.040)g, respectively. The lung metastais counting of group ⅠⅡ was 5.500±0.926,3.375±1.061, respectively.(P<0.05).

关 键 词：肺肿瘤 IL-4 肿瘤转移 肿瘤生长 抑制作用 

分 类 号：R734.2095[医药卫生—肿瘤]