mir-183在食管鳞癌组织中的表达及其与患者预后的关系  

Expression of microRNA-183 in esophageal squamous cell carcinoma and its correlation with disease prognosis

作　　者：彭兵锋[1] 凌志强[2] 罗君[3] 袁嘉敏[3] 郑志国[2] 毛伟敏[2] 

机构地区：[1]温州医学院附属第一医院肿瘤外科,硕士研究生325000 [2]浙江省肿瘤医院 [3]浙江中医药大学研究生部

出　　处：《浙江医学》2013年第10期849-851,855,共4页Zhejiang Medical Journal

基　　金：卫生部科研基金资助项目(WKJ2010-2-004);浙江省自然科学基金资助项目(Y2080749;Y2091110);浙江省科技计划基金资助项目(2009C33143)

摘　　要：目的探讨原发性食管鳞癌(ESCC)组织中mir-183的表达及其与患者临床病理特征、基因表达及预后之间的关系。方法检测83例ESCC组织及癌旁正常组织中mir-183以及基因的表达状况,并对患者的临床病理特征及预后进行分析。结果83例标本中mi r-183表达上调51例(61.4%),mi r-183表达的上调与ESCC患者的淋巴结转移、拓扑异构酶Ⅱ(TopoⅡ)表达及不良预后有关(均P<0.05)。结论 mir-183的表达上调与ESCC的淋巴结转移及TopoⅡ的表达状况有关,并提示预后不良。Objective To investigate the expression of microRNA-183 （mir-183） in esophageal squamous-cell carcino-ma（ESCC）and its correlation with disease prognosis. Methods The expression of mir-183 was detected by real-time RT-PCR and immunohistochemistry in 83 ESCC tissue specimens and corresponding pericancerous tissues. Results Among 83 ESCC samples mir-183 was significantly up-regulated （2~6411-fold） in 51 cases compared to the matching pericancerous tissues. Up-regulation of mir-183 expression was correlated with lymph node metastasis, expression of ToPoⅡ and poor prognosis in ESCC patients （al P〈0.05）. Conclusion Up-regulation of mir-183 expression may indicate the poor prognosis of patients with esophageal squamous cel carcinoma.

关 键 词：mir-183 食管鳞癌 淋巴结转移 拓扑异构酶II 预后 

分 类 号：R735.1[医药卫生—肿瘤]