静脉麻醉对乳腺癌根治术患者皮肤强啡肽和κ受体表达的影响  

The effects of intravenous anesthesia on skin dynorphin and kappa receptor expression

作　　者：贾彬[1] 招伟贤[1] 李国才[1] 洪庆雄[1] 石永勇[1] 陈研生[1] 

机构地区：[1]广州中医药大学附属第二医院麻醉科,广州市510120

出　　处：《临床麻醉学杂志》2013年第6期551-553,共3页Journal of Clinical Anesthesiology

摘　　要：目的探讨不同麻醉药物对乳腺癌根治术患者皮肤强啡肽和κ受体(KOR)表达的影响。方法选取限期行单侧乳腺癌改良根治术患者40例。随机均分为丙泊酚+芬太尼(A组)和丙泊酚+氯胺酮(B组)。麻醉诱导时两组均先予静脉推注丙泊酚2mg/kg,A组静注芬太尼3μg/kg,B组静注氯胺酮1mg/kg。监测术中BP、HR、SpO2和BIS值。于手术开始与手术结束时采集切口边缘皮肤组织0.5cm×2cm,用免疫组化检测强啡肽和KOR的表达。结果手术结束时皮肤强啡肽和KOR的表达均明显高于手术开始时(P<0.01),但两组间差异无统计学意义。结论手术刺激使切口部位皮肤组织强啡肽和KOR的表达增高。不同药物静脉麻醉未对强啡肽和KOR的增高表达产生不同影响。Objective To observe the effects of intravenous anesthesia on skin dynorphin and kappa opioid receptor（KOR） expression. Methods Forty female cases with breast cancer undergoing unilateral radical operation were enrolled in the study. They were randomly divided into two groups with 20 cases each. Group A received propofol-fentanyl, and group B received propofol and ketamine. BP, HR SpO2 and BIS were recorded during operation. 0.5 cm× 2 cm skin samples were taken at the edge of incision. Skin dynorphin and KOR were detected with immunohistochemistry. Results The expressions of dynorphin and KOR were higher at the end of surgery when compared with the beginning of surgery （P 〈 0.01）, without difference between the two groups. Conclusion The expressions of dynorphin and KOR in peripheral skin are up-regulated by the noxious surgical stimulation. Intravenous anesthesia seems to have no protective effect on them.

关 键 词：静脉麻醉 皮肤 强啡肽 Κ阿片受体 

分 类 号：R614[医药卫生—麻醉学]