缺氧诱导因子-1α在膀胱癌中的表达及意义  

Expression and significance of hypoxia-inducible factor-1 α in bladder cancer

作　　者：李然伟[1] 任明[1] 张明[1] 温都苏[1] 刘禄成[1] 

机构地区：[1]吉林大学第二医院泌尿外科,吉林长春130041

出　　处：《中国实验诊断学》2013年第6期1037-1038,共2页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省自然科学基金资助项目(201215077)

摘　　要：目的探讨缺氧诱导因子-1α(HIF-1α)在膀胱癌组织中的表达及其意义。方法采用免疫组织化学技术对30例新鲜的膀胱癌患者的肿瘤组织和15例正常膀胱组织检测HIF-1α的表达情况,比较两组之间的差异。结果 30例膀胱癌组织中23例(76.7%)呈阳性表达,而15例正常膀胱组织中仅1例阳性表达,差异有统计学意义(P<0.05)。结论 HIF-1α蛋白的高表达可能与膀胱癌的发生、发展和复发有关。Objective To discuss expression and significance of hypoxia-inducible factor-1 α（HIF-1α） in bladder cancer.Methods Fresh tissues of 30 cases of bladder cancer and tissues of 15 cases of normal bladder were treated with immunohistochemistry to detect expression of HIF-1α.Difference was compared.Results 23 cases of bladder cancer was positive（76.7%） and 1 case of normal bladder was positive.Difference was significant（P0.05）.Conclusion High expression of HIF-1α protein might have close relationship with genesis,development and relapse of bladder cancer.

关 键 词：膀胱肿瘤 缺氧诱导因子-1Α 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]