鼻咽部滤泡树突状细胞肉瘤的临床病理观察  

Clinicopathologic features of follicular dendritic cell sarcoma in nasopharynx

作　　者：周全[1] 韩一丁[2] 毛美玲[2] 昌红[1] 高颖[1] 刘红刚[2] 

机构地区：[1]首都医科大学附属北京世纪坛医院病理科,北京100038 [2]首都医科大学附属北京同仁医院病理科,北京100730

出　　处：《诊断病理学杂志》2013年第6期344-348,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨鼻咽部滤泡树突状细胞肉瘤的临床病理特点、诊断及鉴别诊断要点。方法回顾分析2例鼻咽部滤泡树突状细胞肉瘤的临床表现、影像学、组织病理学特点及免疫组化表型。结果 2例均为女性,年龄分别为53岁和56岁。肿物最大径分别为4.4 cm和4 cm。2例肿瘤均由梭形细胞组成,细胞片状排列,局部略呈车辐状、束状、旋涡状,细胞异型性不明显。免疫组化:vimentin、CD21和CD23均(+),CK(-);例1 EMA(+),CD35(-),EB病毒(+);例2 CD35(+),EMA(-),EBV(-)。例1放弃治疗,随访2个月,目前带瘤生存;例2接受了肿物扩大切除,术后25个月复发,拒绝再次手术,目前带瘤生存32个月。结论鼻咽部滤泡树突状细胞肉瘤非常罕见,明确诊断需结合组织病理学形态、免疫组化表型及EB病毒检测。Objective To analyze the clinicopathologic features, immunophenotype and differential diagnoses of follicular dendritic cell sarcoma of nasopharynx. Methods Clinical, radiological, histopathological features and immunophenotypes were analyzed in 2 cases of follicular dendritic cell sarcoma in the nasopharynx. Related literatures were reviewed. Results Both cases were female, 53 years old and 56 years old, respectively. Both of the tumors consisted of bland spindle cells, arranging in solid nests, bundles or whorls. Both were positive for vimentin, CD21 and CD23. Neither was positive for CK. Case 1 was positive for EMA and negative for CD35. Case 2 was positive for CD35 and negative for EMA. EBER was detected in case 1. Case 1 refused surgery and radiochemical therapy and survived with tumor （follow-up for 2 months）. Case 2 received operation and suffered recurrence during the follow-up for 25 months. She refused second operation and survived with tumor （follow-up for 32 months ）. Conclusions Follicular dendritic cell sarcoma of nasopharynx is extremely rare. It is important to combine histopathologic features with immunophenotyping and EBV detection.

关 键 词：鼻咽 树突细胞 滤泡 肉瘤 原位杂交 

分 类 号：R739.6[医药卫生—肿瘤]