雷沙吉兰对小鼠肝和脑组织中单胺氧化酶活性的影响  

Effects of rasagiline on monoamine oxidase in mouse liver and brain tissues

作　　者：彭杨[1] 张万萍[1] 程鹏[1] 曾庆东[1] 李文军[1] 鲁振浩[1] 余瑜[1] 

机构地区：[1]重庆医科大学药学院药物化学教研室,重庆400016

出　　处：《重庆医科大学学报》2013年第6期577-579,共3页Journal of Chongqing Medical University

基　　金：国家科技重大专项课题"重大新药创制"资助项目(编号:2010ZX09401-306-1-1)

摘　　要：目的:考察腹腔注射雷沙吉兰对小鼠中肝和脑单胺氧化酶(monoamine oxidase,MAO)活性的抑制作用。方法:采用紫外分光光度法,分别测定低温差速离心法提取小鼠肝和脑组织中的MAO-A和MAO-B活性。结果:雷沙吉兰对MAO-B活性的抑制作用明显强于MAO-A活性;在脑中抑制作用显著比在肝脏中强。结论:雷沙吉兰对小鼠脑内MAO-B活性具有较高的选择性抑制作用。Objective：To investigate the inhibition of rasagiline on monoamine oxidase（MAO） in mouse liver and brain tissues. Methods：After being extracted by differential centrifugation, activities of MAO-A and MAO-B in mouse liver and brain tissues were determined by UV spectrophotometry respectively. Results：Inhibition effect of rasagiline was stronger on MAO-B than on MAO-A and inhibition effect of rasagiline was stronger in the brain than in the liver. Conclusion ：Rasagiline exerts selective inhibition effects on MAO-B in mouse liver and brain tissues.

关 键 词：雷沙吉兰 单胺氧化酶 小鼠 酶活性 抑制作用 

分 类 号：R394.2[医药卫生—医学遗传学]