LEF1和Jagged1在人结直肠癌组织中的表达及其意义  

Expression and significance of lymphoid enhancer factor-1 and Jagged1 in human colorectal carcinoma

作　　者：王文娟[1] 南克俊[1] 王淑红[1] 胡婷华[1] 姜丽丽[1] 马婕群[1] 

机构地区：[1]西安交通大学医学院第一附属医院肿瘤内科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2013年第4期508-511,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81001090)~~

摘　　要：目的探讨淋巴增强因子-1(lymphoid enhancer factor-1,LEF1)和Jagged1在人结直肠癌组织中的表达及其意义。方法采取免疫组化SP法检测184例人结直肠癌组织及184例癌旁正常组织中LEF1和Jagged1的表达,分析两者与人结直肠癌临床病理因素之间的关系。结果 LEF1和Jagged1在人结直肠癌组织中的阳性表达率分别为68.5%和65.8%,均明显高于癌旁正常组织(P<0.001)。LEF1的表达与患者的淋巴结转移、远处转移及TNM分期有关(P<0.05);Jagged1的表达与患者的组织分化程度、淋巴结转移、远处转移及TNM分期有关(P<0.05)。LEF1和Jagged1在结直肠癌组织中的表达呈正相关(r=0.373,P<0.001)。结论 LEF1和Jagged1的高表达与结直肠癌发生发展以及转移密切相关,两者联合检测对人结直肠癌的早期诊断及判断预后具有一定的参考价值。Objective To explore the expression and significance of lymphoid enhancer factor-1（LEF1） and Jagged1 in tissues of human colorectal carcinoma（CRC）.Methods SP immunohistochemistry was used to detect the expression of LEF1 and Jagged1 in 184 human CRC specimens and 184 matched paratumorous normal colorectal specimens.The correlation of LEF1 and Jagged1 expressions with clinicopathological variables of CRC was analyzed.Results Increased expressions of LEF1 and Jagged1 were found in human CRC specimens compared with matched paratumorous normal specimens（P0.001）;the positive rates were 68.5% and 65.8%,respectively.LEF1 expression was significantly associated with lymph node metastasis,distant metastasis,and tumor-node-metastasis（TNM） stage（P0.05）.Meanwhile,Jagged1 expression was significantly associated with tumor cell differentiation,lymph node metastasis,distant metastasis,and TNM stage（P0.05）.Significant positive correlation was found between LEF1 expression and Jagged1 expression in CRC（r=0.373,P0.001）.Conclusion The overexpressions of LEF1 and Jagged1 are closely correlated with carcinogenesis,progression and metastasis of CRC,which suggests that the positive expressions of LEF1 and Jagged1 may be of some value in the early diagnosis and prognosis of human CRC.

关 键 词：结直肠癌 淋巴增强因子-1(LEF1) JAGGED1 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]