蜂胶对创面愈合及局部炎性介质释放的影响  

Effect of propolis on the inflammation in wounded sites

作　　者：肖丽玲[1] 刘宏伟[1] 杜彬[3] 张海伟[3] 朱燕英[2] 

机构地区：[1]暨南大学附属第一医院整形外科,广州510630 [2]暨南大学附属第一医院伤口护理专科 [3]暨南大学医学院病理教研室

出　　处：《中华实验外科杂志》2013年第7期1428-1430,共3页Chinese Journal of Experimental Surgery

基　　金：广东省中医药局基金资助项目（2010117）

摘　　要：目的观察蜂胶对创面愈合的影响。方法建立兔皮肤缺损模型，用蜂胶醇萃取液、磺胺嘧啶银、地塞米松各0．1ml／d处理创面，比较创面愈合速度和质量；检测白细胞介素（IL）-8、IL-18浓度。结果蜂胶醇萃取液、磺胺嘧啶银、地塞米松及对照组创面平均愈合时间分别为（13．75±1．38）、（16．13±1．27）、（17．82±1．18）、（18．05±1．50）d，蜂胶醇萃取液组与各组比较差异有统计学意义（P〈0．05）；组织学观察显示蜂胶醇萃取液组炎性反应小于各组；蜂胶醇萃取液组炎性因子IL-8、IL-18持续于低浓度。结论蜂胶通过抑制IL-8、IL-18释放，调节免疫应答促进创面修复。Objective To observe the effect of propolis on wound healing. Methods The skin wound healing model of rabbits was used. The wound surfaces were treated with propolis extract （0. 1 ml/d, A）, sulfadiazine silver cream （0. l ml/d, B）, dexamethasone injection （0. 1 ml/d, C） respectively. Group D served as blank control. The wound healing was evaluated by the healing rate and histopathological detection. Furthermore, the expression of interleukin （IL） -8 and IL-18 was detected. Results The aver- age time of wound healing was （13.75＋1.38）, （16. 13＋1.27）, （17.82＋1.18） and （18.05＋1.50） days in groups A, B, C and D. Statistical analysis showed that the time of wound healing in group A was significantly shorter than the rest （ P 〈 0.05 ）. Based on observation of histopathological change, inflamma- tory response could be obviously decreased in group A as compared with the rest. Moreover, the expression of IL-8 and IL-18 was lower in group A than the rest. Conclusion Propolis can reduce the inflammatory reaction and accelerate wound healing by inhibiting the IL-8 and IL-18.

关 键 词：溃疡 蜂胶 白细胞介素-8 创面愈合 

分 类 号：R[医药卫生]