SRC-3及FBXW7在宫颈癌中的表达及临床意义  

Expression and clinical significance of SRC-3, FBXW7 in cervical carcinoma

作　　者：韩丹丹[1] 王贵吉[1] 裴迎新[2] 张丽静[1] 王姗[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,450052 [2]郑州大学公共卫生学院营养与食品卫生学教研室

出　　处：《中国实用医刊》2013年第14期49-52,共4页Chinese Journal of Practical Medicine

摘　　要：目的初步研究宫颈癌中类固醇受体辅助活化因子-3（SRC-3）、F框／WD40域蛋白7（FBXW7）的表达及临床意义。方法应用免疫组化SP法检测60例宫颈癌组织、20例正常宫颈组织中SRC3、FBXW7的表达情况。结果SRC-3在宫颈癌、正常宫颈组织中的表达率分别为33．3％、10．0％，两者间比较差异无统计学意义（P〉0．05），但随着肿瘤分化程度的逐渐降低，SRC-3的表达水平有不断增高的趋势。SRC-3的阳性表达率与宫颈癌的分化程度、临床分期、淋巴结转移有相关性。FBXW7在宫颈癌、正常宫颈组织中的表达率分别为48．3％、90．0％，两者之间的差异有统计学意义（P〈0．05），且与宫颈癌的分化程度、临床分期、淋巴结转移有关（P〈0．05）；SRC-3与FBXW7之间存在着负相关关系（r=-0．259，P=0．045）。结论SRC-3、FBXW7有可能成为宫颈癌早期诊断、判断预后的新指标及治疗靶点。Objective To study the expression and clinical significance of steroid receptor rcoaetivator-3 （ SRC-3 ） and F-box/WD repeat-containing protein 7 （ FBXW7 ） in cervical carcinoma. Methods Immunohistochemistry was used to examine the expressions of SRC-3 and FBXW7 in cervical carcinoma and normal cervical tissues. Results The positive rates of SRC-3 in cervical carcinoma and normal tissue were 33.3% and 10.0% , there was no significant difference（ P =0. 083 〉0.05） , but with differentiation degree of cervical carcinoma gradually reduced, SRC-3 expression level had a increasing trend, and the expression of SRC-3 was significantly correlated with differentiation degree, clinical stage and lymph node metastasis（ P 〈0.05）. The positive rate of FBXW7 in cervical carcinoma and normal tissue was 48.3% and 90. 0% respectively, there was significant difference（ P 〈0. 05 ） ; and the expression of FBXW7 was significantly correlated with differentiation degree, clinical stage and lymph node metastasis （ P 〈 0.05 ）. And there was a negative correlation of SRC-3 with FBXW7 （ r = - 0. 259, P = 0. 045）. Conclusions SRC-3, FBXW7 may be a new indicators and therapeutic targets for early diagnosis and prognosis evaluation of cervical cancer.

关 键 词：宫颈癌 类固醇受体辅助活化因子-3 F框 WD-40域蛋白7 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]