Allophylus africanus和Tragia benthamii的植物化学筛选、抗疟疾及组织病理学研究(英文)  

Phytochemical screening,antimalarial and histopathological studies of Allophylus africanus and Tragia benthamii

作　　者：Oladosu I.A. Balogun S.O. Ademowo G.O. 

机构地区：[1]Department of Chemistry,University of Ibadan,Ibadan,Nigeria [2]Department of Chemistry,Obafemi Awolowo University,Ile-Ife,Osun-State,Nigeria [3]Institute of Medical Research and Training,College of Medicine,University of Ibadan,Ibadan,Nigeria

出　　处：《中国天然药物》2013年第4期371-376,共6页

摘　　要：The anti-malarial potential of different parts of Allophylus africanus P.Beauv and Tragia benthamii Baker were determined in vivo for suppressive,curative and cytotoxic activities in mice receiving 0.2 mL of a standard inoculum size of 1 × 107 infected erythrocytes of Plasmodium berghei(NK-65) intraperitoneally.The A.africanus extracts suppressed parasitaemia following administration to infected mice by 92.82% 97.81% on day 7 post-infection against 96.81% for chloroquine.The infected extract-treated animals had significantly moderate(P < 0.05) packed cell volume(PCV) compared with the infected,untreated animals.Phytochemical screening revealed a predominance of tannins,saponins,flavonoids and carbohydrates in all parts of A.africanus,and alkaloids instead of flavonoids in the extract of T.benthamii.The results suggest that the extract possesses considerable antimalarial activity.These results support further studies on A.africanus.The anti-malarial potential of different parts of Allophylus africanus P.Beauv and Tragia benthamii Baker were determined in vivo for suppressive,curative and cytotoxic activities in mice receiving 0.2 mL of a standard inoculum size of 1 × 10^7 infected erythrocytes of Plasmodium berghei（NK-65） intraperitoneally.The A.africanus extracts suppressed parasitaemia following administration to infected mice by 92.82% 97.81% on day 7 post-infection against 96.81% for chloroquine.The infected extract-treated animals had significantly moderate（P 〈 0.05） packed cell volume（PCV） compared with the infected,untreated animals.Phytochemical screening revealed a predominance of tannins,saponins,flavonoids and carbohydrates in all parts of A.africanus,and alkaloids instead of flavonoids in the extract of T.benthamii.The results suggest that the extract possesses considerable antimalarial activity.These results support further studies on A.africanus.

关 键 词：实验药理学 药理 病理作用 天然药物 

分 类 号：R965[医药卫生—药理学]