山楂核中具有抗肿瘤活性化合物的分离(英文)  

Isolation of cytotoxic compounds from the seeds of Crataegus pinnatifida

作　　者：李玲芝[1] 彭缨[2] 牛超[1] 高品一[3] 黄肖霄[1] 毛新良[4] 宋少江[1,5] 

机构地区：[1]沈阳药科大学中药学院,沈阳110016 [2]沈阳药科大学药学院,沈阳110016 [3]沈阳化工大学化学工程学院,沈阳110142 [4]苏州大学医学部药学院,苏州215123 [5]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,沈阳110016

出　　处：《中国天然药物》2013年第4期411-414,共4页

基　　金：supported by the China National Fundamental Fund of National Science Talent Training Base in pharmacy(No.J1103606);the Scientific Research Starting Foundation for Doctors of Liaoning Province of China(No.20121106);the Foundation from the Project of Education Department of Liaoning Province,China(No.L2012358);Innovative Research Team of the Ministry of Education;Program for Liaoning Innovative Research Team in University~~

摘　　要：目的:对山楂核的化学成分及生物活性进行研究。方法:运用大孔吸附树脂D101,硅胶,ODS和制备高效液相色谱等方法分离化合物,通过多种波谱方法进行结构鉴定。此外,还对化合物进行了OPM2和RPMI-8226两组细胞株的细胞毒活性测试。结果:从山楂核中得到4个化合物:(7S,8S)-4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethoxy]-3,5-dimethoxybenzaldehyde(1),(+)-balanophonin(2),erythro-guaiacylglycerol-β-coniferylaldehydeether(3),buddlenolA(4)。结论:化合物1为一新降木脂素。化合物24为属内首次分离得到。活性测试结果表明化合物14的抗肿瘤活性不明显。AIM： To study the chemical constituents and bioactivity of the seeds of Crataegus pinnatifida. METHODS： The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activities of compounds 1-4 were investigated on OPM2 and RPMI-8226 cells. RESULTS： Four compounds were obtained and their structures were identified as （7S, 8S）-4-β-hydroxy-2-（4-hydroxy-3-methoxyphenyl）-l-（hydroxymethyl）ethoxy]-3, 5-dimethoxybenzaldehyde （1）, （＋）-balanophonin （2）, erythro-guaiacylglycerol-fl-coniferyl aldehyde ether （3）, buddlenol A （4）. CONCLUSION： Compound 1 is a novel norlignan, while compounds 1-4 exhibited marginal inhibition on the proliferation of OPM2 and RPMI-8226 cells.

关 键 词：山楂 降木脂素 生物活性 

分 类 号：R284.1[医药卫生—中药学]