尿液透明质酸酶活性检测在膀胱癌中的诊断意义  

Clinical Significance of Urine Hyaluronidase Activity in Patients with Bladder Cancer

作　　者：李云慧[1] 彭婧[2] 

机构地区：[1]解放军第202医院检验科,沈阳110003 [2]中国医科大学95期26班

出　　处：《中国实用乡村医生杂志》2013年第12期50-52,共3页Chinese Practical Journal of Rural Doctor

基　　金：辽宁省科技厅基金项目,项目编号：2011225021

摘　　要：目的探讨尿液透明质酸酶（HYAL）活性检测在膀胱癌诊断中的意义。方法选取75例膀胱癌患者（恶性组）、53例泌尿系统良性疾病患者（良性组）$N40例健康体检人群（正常对照组）为研究对象。用酶联免疫吸附法（ELISA）~q定尿液HYAL活性。结果恶性组尿液HYAL活性显著高于良性组和对照组（p〈0．01），良性组尿液HYAL活性高于正常对照组（P〈O．01）。膀胱癌患者尿液HYAL活性与淋巴结转移、复发和病理分期有关。尿液HYAL活性的ROC曲线下面积为0．855（P〈0．01）。尿液HYAL活性和尿脱落细胞学的联合诊断的灵敏度为83．8％，特异度为98．3％。结论HYAL可能与膀胱癌的发生、发展和转移有关，尿液HYAL活性的检测可以用于膀胱癌的辅助诊断。Objective To evaluate hyaluronidase （HYAL） activity for diagnosis of bladder cancer. Methods 75 patients with bladder cancer （malignant group）, 53 patients with urological disorder （benign group） and 40 healthy controls were included in this study. Urine HYAL activity were measured by using ELISA methods. Results Urine HYAL activity in malignant group was higher significantly than those in benign group and healthy controls （P〈0.01）. Urine HYAL activity in benign group was higher than that in healthy controls （P〈0.01）. Urine HYAL activity correlated to lymph node metastasis, reoccurrence, and tumor grade. Receiver operating characteristic （ROC） curves of urine HYAL activity was 0.855（P〈0.01）. The combined detection of urine HYAL activity and urine cytology reached the highest sensitivity of 83.8% and specificity of 98.3%. Conclusion HYAL may be closely associated with the progression of bladder cancer. Urine HYAL activity may represent the helpful adjunct to conventional diagnostic tools in bladder cancer.

关 键 词：膀胱癌 透明质酸酶 尿液 诊断 

分 类 号：R737[医药卫生—肿瘤]