MMP3在肿瘤发生发展中作用的新进展  

Research Progress on the Role of MMP3 in the Development of Tumor

作　　者：胡涂[1] 曾乐平[1] 黄菊芳[1] 

机构地区：[1]中南大学基础医学院人体解剖学与神经生物学系,湖南长沙410013

出　　处：《肿瘤药学》2013年第3期166-171,共6页Anti-Tumor Pharmacy

基　　金：教育部新教师基金资助项目(20100162120072);国家自然基金资助项目(81100663)

摘　　要：基质金属蛋白酶3(matrix metalloproteinase3,MMP3)是MMPs家族的主要成员之一,其前肽区(propeptide,Pro)和铰链(hinge,H)之间的具有Zn2+活性位点的接触反应性核团(catalytic domain)是其核心反应部位。MMP3在机体内表达的变化和活性的异常参与了多种疾病的病理过程,特别是肿瘤的发生与发展过程。本文将从MMP3的结构、功能、生物化学特性及其在肿瘤发生发展中的作用等方面综述其最新研究进展。Matrix metaUoproteinase 3 （MMP3） is attached to the family of Matrix metalloproteinases （MMPs）. And the cata- lyric domain, which is located between the propeptide （Pro） and the hinge and has an active site with Zn^2＋, is the cardinal active site of MMP3. Its change in gene expression and its abnormal activity contribute to the pathologic processing of many diseases, especially to the development of tumor. This review is aimed at introducing and elaborating MMP3 through its structure, func-tion, biochemistry and its contribution in tumor progression,

关 键 词：MMP3 TIMP1 基因多态性 肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]