气相色谱-质谱法测定奶瓶中双酚A含量  

GC-MS Determination of Bisphenol A in Feeding-Bottle

作　　者：李少霞[1] 黄伟雄[1] 余胜兵[1] 刘锐[1] 陈明[1] 姚敬[1] 

机构地区：[1]广东省疾病预防控制中心,广州510300

出　　处：《理化检验（化学分册）》2013年第6期679-682,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：广东省医学科研基金(A2011062)

摘　　要：提出了气相色谱-质谱法测定奶瓶中双酚A含量的方法。取剪碎的样品经二氯甲烷溶解,甲醇提取后,所得净化液中双酚A与N,O-双(三甲基硅烷基)三氟乙酰胺-三甲基氯硅烷(99+1)溶液进行衍生化反应,产物用乙酸乙酯定容。在气相色谱分离中用DB-5MS毛细管柱为固定相,在质谱分析中采用选择离子监测模式。双酚A的质量浓度在10.0～200.0μg·L-1范围内与峰面积呈线性关系,测定下限(10S/N)为1.0mg·kg-1。方法用于奶瓶中双酚A的测定,回收率在77.5%～95.1%之间,相对标准偏差(n=6)为3.9%。A method of GC-MS for determination of bisphenol A in feeding-bottle was proposed.The sheared sample was dissolved with CH2Cl2 and extracted with methanol,then derivatized with N,O-bis（trimethyl-silanyl）-trifluoro-acetamide-trimethylchloro silane（99＋1） solution.The derivatized product was dissolved with ethyl acetate.DB-5MS capillary column was used for GC separation and selected ion monitoring mode were adopted in MS determination.Linear relationship between values of peak area and mass concentration of bisphenol A was obtained in the range of 10.0-200.0 μg·L-1,with lower limit of determination（10S/N） of 1.0 mg·kg-1.The proposed method was applied to the analysis of feeding-bottle,giving values of recovery in the range of 77.5%-95.1% and RSD（n=6） of 3.9%.

关 键 词：气相色谱-质谱法 双酚A 奶瓶 

分 类 号：O657.63[理学—分析化学]