那他霉素联合重组牛碱性成纤维细胞生长因子眼用凝胶治疗真菌性角膜溃疡的疗效  

Efficacy observation of the fungal keratitis treated by the Natamycin and recombinant bovine basic fibroblast growth factor ophthalmic gel

作　　者：渠晓黎[1] 赵桂秋[1] 高昂[1] 车成业[1] 林静[1] 胡丽婷[1] 李翠[1] 陈文俊[1] 

机构地区：[1]青岛大学医学院附属医院眼科,中国山东省青岛市266003

出　　处：《国际眼科杂志》2013年第7期1322-1325,共4页International Eye Science

基　　金：国家自然科学基金资助项目(No.81170825)~~

摘　　要：目的:探讨那他霉素、重组牛碱性成纤维细胞生长因子眼用凝胶点眼联合碘酊烧灼治疗真菌性角膜溃疡的疗效。方法:将160例真菌性角膜溃疡的患者随机分为治疗1组(60例)、治疗2组(67例)和对照组(33例)。三组病例均先行局部清创碘酊烧灼术,治疗1组采用50g/L那他霉素滴眼液点眼,治疗2组采用50g/L那他霉素滴眼液及重组牛碱性成纤维细胞生长因子眼用凝胶点眼,对照组使用2g/L氟康唑滴眼液点眼,比较三组病例的治愈率和疗程。结果:三组治愈率分别为71.7%,76.1%,51.5%,有效率分别为90.0%,91.0%,78.8%。治疗1,2组分别与对照组相比,差异有统计学意义(P<0.05)。三组中治愈病例的平均治愈时间分别为20±15,16±12,30±13d,治疗组与对照组比较均有显著统计学意义。结论:抗真菌药物50g/L那他霉素滴眼液及细胞生长因子重组牛碱性成纤维细胞生长因子眼用凝胶与传统的碘酊烧灼法联合治疗真菌性角膜溃疡,尤其是早期患者,具有重要意义。AIM ： To investigate the effect of the treatment of fungal keratitis with natamycin, recombinant bovine basic fibroblast growth factor eye gel and iodine cautery. METHODS： Totally 160 fungal keratitis patients were randomly divided into test group one （60 cases）, group two （67 cases） and control group （33 cases）. Three groups were all treated by iodine cautery at first. Then the test group was treated with 50g/L natamycin eye drops and the test group two was given 50g/L natamycin and bFGF eye gel. The control group was only treated by 2g/L fluconazole eye drops. Then the therapeutic effect and duration of treatment between the three groups were analyzed. RESULTS： The cure rates of three treatment groups were 71.7%, 76.1% and 51.5%, respectively. The effective rates were 90.0%, 91.0% and 78.8%, respectively. There were statistical differences between two test groups and the control group P 〈0. 05）. The average healing time of cured cases in the three groups were 20±15, 16±12, 30±13d, respectively. There were statistically significantdifferences between the two test groups and the control group. CONCLUSION： The combined treatment of novel antifungal 50g/L natamycin, cell growth factor bFGF with traditional iodine cauterization is remarkable effective for fungal keratitis, especially early stage patients.

关 键 词：那他霉素 重组牛碱性成纤维细胞生长因子 真菌 性 角膜溃疡 

分 类 号：R772.21[医药卫生—眼科]