玻璃体腔注射曲安奈德减轻视网膜静脉阻塞继发的黄斑水肿  

Macular edema owing to retinal vein occlusion treated by intravitreal triamcinolone acetonide

作　　者：刘伟[1] 程扬[1] 

机构地区：[1]华中科技大学附属协和医院眼科,中国湖北省武汉市430022

出　　处：《国际眼科杂志》2013年第7期1406-1407,共2页International Eye Science

摘　　要：目的:评估玻璃体腔内注射曲安奈德(triamcinolone acetonide,TA)治疗视网膜静脉阻塞(retinal vein occlusion,RVO)引起的黄斑水肿的长期安全性与有效性。方法:患者17例17眼出现视网膜静脉阻塞引起的黄斑水肿,接受玻璃体腔内注射2mgTA,随访1a,监测患者视力、黄斑厚度。结果:随访发现,15眼(88%)视力得到明显改善,从术前0.114±0.068增加到术后的0.184±0.094,差异有统计学意义(P<0.05),而中央黄斑区的厚度从术前的514.0±67.4μm减少到术后的442.0±61.5μm,差异有统计学意义(P<0.05)。术后6例患者出现短期眼压升高,并无并发性白内障,玻璃体出血,视网膜脱离以及眼内炎的发生。结论:玻璃体腔内注射TA能长期有效减缓RVO引起的黄斑水肿。AIM： To intravitreal assess the long-term safety triamcinolone management of macular occlusion （RVO）. acetonide （ TA） edema caused and efficacy of injection in the by retinal vein METHODS： This prospective, interventional case series included 17 patients （17 eyes） with RVO and macular edema. They received an intravitreal injection of 2mg TA. Follow-up was for 1 year. Outcome measures were visual acuity and macular thickness measured using ocular coherence tomography （OCT）. RESULTS： In our group, visual acuity measurements showed that 15 eyes （88%） had improved visual acuity, and mean visual acuity increased from 0. 114± 0. 068 preoperatively to a postoperative visual acuity of 0. 184± 0.094 （P〈 0. 05）. The central macular thickness was reduced from 514.0±67.4μ m to 442.0±61.5μ m （P〈0.05）. Six patients in the study suffered a rise in intraocular pressure （lOP） （35%） temporarily. There was no case of visually significant cataract, vitreous haemorrhage, retinal detachment, or endophthalmitis. CONCLUSION： Intravitreal injection of triamcinolone acetonide can effectively improve the macular edema caused by retinal vein occlusion.

关 键 词：视网膜静脉阻塞 曲安奈德 黄斑水肿 

分 类 号：R774.5[医药卫生—眼科]