溃疡性结肠炎与5-羟色胺转运体基因多态性的关系  

Association between serotonin transporter gene polymorphisms and ulcerative colitis

作　　者：朱炳喜[1] 罗冠琴[1] 

机构地区：[1]徐州医学院附属医院消化内科,江苏徐州221002

出　　处：《中国中西医结合消化杂志》2013年第6期284-286,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：江苏省徐州市科技局基金资助项目(No:XF10C067)

摘　　要：[目的]探讨溃疡性结肠炎(UC)与5-羟色胺转运体启动区(5-HTTLPR)基因多态性的关系。[方法]聚合酶链反应技术检测30例UC患者(病例组)与30例健康对照组5-HTTLPR多态性的分布频率。[结果]病例组5-HTTLPR的S/S基因频率为50.0%,健康对照组S/S基因频率为33.3%,2组之间比较差异有统计学意义(P<0.05)。病例组5-HTTLPR的L/S、L/L的基因频率分别为40.0%、10.0%,健康对照组L/S、L/L的基因频率分别为43.3%、23.3%,2组之间比较,差异无统计学意义(P>0.05)。[结论]5-HTTLPR的S/S基因型可能与UC的发病有关。[Objective]To explore the association between ulcerative colitis （UC） and the polymor- phisms of serotonin transporter （SERT） gene-linked polymorphic region （5-HTTLPR）. [Methods]Poly- merase chain reaction （PCR） was used to detect 5-HTTLPR polymorphism of SERT gene in 30 patients with UC and in 30 control subjects. [Results]The S/S genotype frequency of 5-HTTLPR alleles was signif- icantly higher in UC patients than in controls （ 50. 0% vs 33. 3%; both P〈0. 05）. The 5-HTTLPR geno- types frequencies showed that L/L was 10.0%, L/S was 40.0% in UC patients, and L/L23.4%, L/S 43.3% in control subjects, there was no difference between UC patients and controls subjects （P〈0. 05）. [Conclusion]5-HTTLPR L/L genotype may play an inportant role in the pathogenesis of ulcerative colitis.

关 键 词：结肠炎 溃疡性 5-羟色胺转运体基因 多态性 

分 类 号：R574.62[医药卫生—消化系统]