人类组织激肽释放酶7在前列腺癌与增生组织中表达的差异及意义  

Expression difference and significance of human kallikrein 7 in prostate tissues

作　　者：黄逢雨[1] 莫曾南[2] 

机构地区：[1]烟台市莱阳中心医院泌尿外科,山东265200 [2]广西医科大学泌尿科学研究所

出　　处：《医学动物防制》2013年第6期607-609,F0003,共4页Journal of Medical Pest Control

摘　　要：目的研究人类组织激肽释放酶7(human tissue kallikreins 7,hK7)在正常前列腺、前列腺增生和前列腺癌3种组织中表达的差异及其意义。方法采用免疫组化法,利用组织芯片检测正常前列腺、前列腺增生及前列腺癌组织中hK7蛋白的表达情况。结果 hK7的表达在正常前列腺、前列腺增生和前列腺癌3种组织之间差异有统计学意义(P=0.014),在前列腺癌中的表达要比在正常前列腺及前列腺增生中的表达下降(P<0.05);而hK7在正常前列腺和前列腺增生中的表达水平之间差异无统计学意义。结论在前列腺癌组织中hK7的表达较正常和增生前列腺组织降低,hK7可能具有潜在抑制前列腺癌的作用。Objective To investigate the expression difference and significance of human tissue kallikreins 7 （hK7） in normal prostate, benign prostatic hyperplasia （BPH） and prostate carcinoma. Methods An immu- nohistochemical assay was used to detect the expression of hK7 in normal prostate tissue, BPH and prostate carcinoma. Results There were significant differences of hK7 expression among normal prostate, BPH and prostate carcinoma. The hK7 positive expression in prostate carcinoma was significantly lower than that in BPH and normal prostate. There was no significant difference of the hK7 expression between BPH and normal pros- tate. Conclusions The hK7 expression in prostate carcinoma is significantly lower than that in BPH and normal prostate. The hK7 in prostate carcinoma may have an inhibitory effect on prostate tumor.

关 键 词：人类组织激肽释放酶7(hK7) 前列腺增生 前列腺癌 肿瘤标志物 组织芯片 

分 类 号：R737.25[医药卫生—肿瘤]