血清瘦素在小细胞肺癌患者中的表达及临床意义  

Expression of Serum Leptin in Small Cell Lung Cancer and Its Clinical Significance

作　　者：洪璇[1] 田凤鸣[2] 陈公琰[1] 崔宝红[1] 王萌[1] 杨朝阳[1] 

机构地区：[1]哈尔滨医科大学附属第三医院,黑龙江哈尔滨150081 [2]黑龙江省公安厅安康医院,黑龙江哈尔滨150039

出　　处：《肿瘤学杂志》2013年第6期427-430,共4页Journal of Chinese Oncology

摘　　要：[目的]分析血清瘦素(leptin)水平与小细胞肺癌(SCLC)患者临床病理特征的关系,探讨血清leptin水平是否能够作为SCLC独立的风险因素。[方法]应用酶联免疫吸附法检测41例SCLC患者及51名健康人(对照组)的血清leptin表达水平。[结果]SCLC组与对照组血清leptin平均水平分别是(6.45±2.55)ng/ml和(7.05±2.61)ng/ml,两组间差异无统计学意义(P=0.900)。血清leptin水平与SCLC患者的年龄、吸烟状态以及分期、PS评分无相关性(P>0.05),然而与性别、体质指数(BMI)以及SCLC患者体重下降存在相关性(P<0.05)。[结论]血清lep-tin水平并不能作为SCLC独立的风险因素,但其与SCLC患者营养状况以及恶病质存在相关性,可以作为判断肿瘤营养状态的指标之一。Purpose To investigate the relationship between serum leptin and clinicopathologic features in patients with small cell lung cancer（SCLC） . Methods Serum leptin was determined in 41 patients with SCLC and 51 healthy controls with the ELISA method. Results The mean leptin level was （6.45±2.55）ng/ml in patients with SCLC and （7.05±2.61）ng/ml in controls,without significant difference between the two groups. Serum leptin level did not correlate to age,smoking,stages and performance status （P0.05）,but it positively correlated to gender,BMI and weight loss （P0.05）. Conclusion Serum leptin may not be considered as a independent risk factor for SCLC. However,it correlates to nutrition status and cachexia in patients with SCLC. It may be as a marker to evaluate patients’ performance status.

关 键 词：瘦素 癌 小细胞肺 酶联免疫吸附法 

分 类 号：R734.2[医药卫生—肿瘤]