颌下腺癌在多形性腺瘤中预后因素分析  

Prognostic Factors of Carcinoma ex Pleomorphic Adenoma (CXPA) from Submandibular Gland

作　　者：陈超[1] 王佳峰[1] 赵坚强[1] 葛明华[1] 

机构地区：[1]浙江省肿瘤医院,浙江杭州310022

出　　处：《肿瘤学杂志》2013年第6期461-465,共5页Journal of Chinese Oncology

摘　　要：[目的]分析颌下腺起源的癌在多形性腺瘤中(CXPA)的预后及其影响因素,探讨其合理治疗。[方法]回顾性分析25例颌下腺起源的CXPA的临床及随访资料。所有患者均行原发灶根治性手术切除,8例接受了术后放疗。[结果]全组复发转移率为52.0%,5年总体生存率和肿瘤相关生存率分别为48.0%和53.9%。单因素分析结果显示病理分级、T分期、淋巴结转移和临床分期对颌下腺CXPA生存率的影响有统计学意义(P<0.05),侵袭性对生存率的影响接近有统计学意义(P=0.092)。COX多因素分析显示:淋巴结转移与颌下腺CXPA的生存率有关(P<0.05)。[结论]淋巴结转移是颌下腺CXPA的独立预后因素。根治性手术以及合理的术后放疗是其治疗的主要方法。Purpose To investigate the prognostic influencing factors of carcinoma ex pleomorphic adenoma （CXPA） arisen from submandibular gland,and the reasonable treatment for it. Methods Clinical and following-up data of 25 cases with CXPA of submandibular gland were analyzed retrospectively All the cases underwent radical resection and in which 8 cases accepted postoperative radiotherapy. Results The overall recurrence was 52.0%,and 5-year overall survival and tumor-related survival were 48.0% and 53.9% respectively. Univariate analysis showed that histological grading,T staging,lymph node metastasis and clinical staging were prognostic influencing factors with statistical significance（P0.05）. Invasiveness seemed impacting on prognosis but without statistical significance（P=0.092）. COX multivariate analysis showed that lymph node metastasis had impact on CXPA’s survival（P0.05）. Conclusion Lymph node metastasis is an independent prognostic factor for CXPA of submandibular gland. Radical resection and reasonable postoperative radiotherapy are the predominant treatment methods.

关 键 词：涎腺肿瘤 颌下腺 癌在多形性腺瘤中 预后 

分 类 号：R739.8[医药卫生—肿瘤]