95例疑难性肝病患者肝脏病理学特点分析  

Liver histology characteristics analysis of 95 patients with complicated liver disease

作　　者：郭卉[1] 官阳[2] 齐俊英[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院感染科,湖北武汉430030 [2]华中科技大学同济医学院病理学系超微病理研究室

出　　处：《中西医结合肝病杂志》2013年第3期142-144,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨疑难性肝病患者的临床及肝脏病理学特点。方法:回顾性分析总结我科2009年1月-2011年7月收治的95例疑难性肝病患者的临床资料及肝穿刺活检标本的光镜及电镜结果。结果:95例患者中,确诊46例,占48.42%;其中通过病理直接确诊26例,结合检查与治疗确诊20例。高度怀疑17例(17.89%),仍未明确诊断者32例(33.69%)。确诊疾病的前3位为:先天性非溶血性黄疸、自身免疫性肝病、淤胆型肝炎。结论:肝穿刺活检对疑难性肝病的确诊很有帮助,特别是电镜检查对先天性非溶血性黄疸、类脂质代谢障碍、糖代谢障碍及肝脏淀粉样变性等疾病的诊断有独到之处。Objective： To explore the clinical and liver pathology features of the complicated liver disease patients.Methods： Optical and electron microscopy results of the liver biopsy specimens and clinical data of 95 cases of patients with complicated liver disease who were admittted in our department from 2009.1 to 2011.7 were analyzed retrospectively（all patients had liver histological examination）.Results： In 95 patients,diagnosed 46 cases,accounting for 48.42%;26 cases which directly diagnosed by pathological and the other 20 cases were diagnosed by examination and treatment.Highly suspected in 17 cases（17.89%）,yet a clear diagnosis in 32 cases（33.69%）.Diagnosed with the disease before 3： congenital hemolytic jaundice,autoimmune liver disease,cholestatic hepatitis.Conclusion： Liver biopsy are helpful to the diagnosis of the disease,especially the Electron microscopy（EM） examination in congenital hemolytic jaundice,Class of lipid metabolism disorders,Impaired glucose metabolism and Liver amyloidosis.

关 键 词：疑难性肝病 肝穿刺活检 光镜检查 电镜检查 

分 类 号：R575[医药卫生—消化系统]