抗抑郁治疗伴有抑郁症状的功能性胃肠病患者疗效观察  

The clinical effect of fluoxertine hydrochloride on the patients with functional gastrointestinal disorder and depression symptoms

作　　者：吴惠 杜德伟[2] 

机构地区：[1]海军总医院干部保健科,北京100841 [2]第四军医大学唐都医院肾脏内科,陕西西安710038

出　　处：《实用医院临床杂志》2013年第4期117-119,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨盐酸氟西汀治疗伴有抑郁症状的功能性胃肠病患者的临床效果。方法将158例伴有抑郁症状的功能性胃肠病患者按随机数字表法分为盐酸氟西汀治疗组(A组)和莫沙必利治疗组(B组)各79例,分别单纯采用盐酸氟西汀和莫沙必利治疗,疗程均为4周。结果治疗后两组的平均症状积分均明显下降,与治疗前比较差异有统计学意义(P<0.01);A组Zung积分较B组显著下降(P<0.01)。结论精神心理障碍会导致功能性胃肠病,对有抑郁倾向的患者抗抑郁治疗在改善患者抑郁症状的同时能够改善患者的胃肠功能。Objective To observe the gastrointestinal effects of fluoxetine hydrochloride on patients with functional gastrointestinal disorder and depression symptoms. Methods Three hundred and ninety-six patients with functional gastrointestinal disease and depression symptoms that was assessed through the Zung Depression Scale were randomly divided into fluoxetine hydrochloride treated group f group A） and mosapr/de citrate treated group （B group）. The course of treatment was 4 weeks. Results Before treatment, there was no significant difference of Zung integration between the two groups. After treatment,Zung integration in the A group was sig- nificantly decreased compared to the B group （P 〈0.01 ）. The average symptom score in the two groups were decreased significantly. The score of curative effect was significantly different between the two groups （P 〈0. 01 ）. Conclusion Mental disorder can lead to functional gastrointestinal disorders. The gastrointestinal function in patients with functional gastrointestinal disorder could be improved by antidepressant therapy.

关 键 词：功能性胃肠病 盐酸氟西汀 抑郁 

分 类 号：R574.4[医药卫生—消化系统] R719.8[医药卫生—内科学]