烫伤对大鼠视上核精氨酸加压素阳性细胞的影响  

Effect of Scald on Arginine Vasopressin Positive Cells in the Supraoptic Nucleus in Rats

作　　者：王成海[1] 宋朝佑[1] 范溥生 何润昌 汪定涛 周世臣[2] 张忠义[2] 

机构地区：[1]第二军医大学训练部神经生物学教研室,200433 [2]第二军医大学训练部解剖学教研室,200433

出　　处：《第二军医大学学报》1991年第1期17-20,共4页Academic Journal of Second Military Medical University

摘　　要：本研究应用免疫组织化学和计算机图像分析技术,定量研究了烫伤对大鼠视上核精氨酸加压素(AVP)阳性细胞分泌的影响。实验结果表明:大鼠烫伤后视上核AVP阳性反应物体积减小,尤以烫伤后即刻最为显著(P<0.01);而视上垂体束纤维串珠样结构却略有增加。说明大鼠烫伤时,从下丘脑视上核AVP阳性细胞胞体向垂体后叶运送AVP的量增加。本研究从形态学角度提示了AVP参与大鼠烫伤后应激反应的过程。In this study, image quantitative analysis was made to investigate the effect of scald on arginine vasopressin (AVP) positive cells in the supraoptic nucleus (SON) stained with immunohistochemical method. Results showed that there was a decrease in the volume of AVP positive substance in the cells of SON following scald, which was significant immediately after scald (P<0. 01). In contrast with the control, beads-like substance in the supraoptic-hypophyseal tract was increased,suggesting that there was an increased release of AVP from SON to the posterior pituitary in the rats subjected to scald.This study provides morphological evidences for the involvement of AVP in the process of stress reaction following scald.

关 键 词：烫伤 视上核 精氨酸加压素 

分 类 号：R644.02[医药卫生—外科学]