supported by the Anhui Provincial Natural Science Foundation,China(No.1408085MH155);the Natural Science Foundation of the Department of Education,Anhui Province,China(No.KJ2012B203);the National Natural Science Foundation of China(No.31271155,31200828);Cultivate Foundation of Wannan Medical College(No.WK2013Z03);Scientific Research Foundation for Ph.D. of Wannan Medical College,China(No.201402)