This work was supported by the National Natural Science Foundation of China(81960216,81903595,81860216,and 32060186)and the Natural Science Foundation of Jiangxi Province(20202BABL206049 and 20202BAB216043).
The thalamocortical(TC)circuit is closely asso-ciated with pain processing.The hyperpolarization-activated cyclic nucleotide-gated(HCN)2 channel is predominantly expressed in the ventral posterolateral thalamus(VPL)th...
supported by the National Key Research and Development Program of China(2021ZD0203100);the National Natural Science Foundation of China(32025017,32121002,82171218,82101300,82101301);the CAS Project for Young Scientists in Basic Research(YSBR-013);the Youth Innovation Promotion Association CAS;the CAS Collaborative Innovation Program of Hefei Science Center(2021HSC-CIP013);the Fundamental Research Funds for the Central Universities(WK9100000030);the USTC Research Funds of the Double First-Class Initiative(YD9100002018);the Natural Science Foundation of Anhui Province(2208085J30,2008085 QC114);the Innovative Research Team of High level Local Universities in Shanghai。
Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain re...
supported by grants from the National Natural Science Foundation of China (85100929);the Natural Science Foundation of Hubei Province,China (2018CFB302 and 2019CFB446);the Youth Fund of Health and Family Planning Commission of Wuhan Municipality,Hubei Province,China (WX18Q13 and WX18Q22)。
In the central nervous system,hyperpolarizationactivated cyclic nucleotide-gated(HCN)channels are essential to maintain normal neuronal function.Recent studies have shown that HCN channels may be involved in the patho...
目的:观察HCN1,HCN2在功能性便秘(function constipation,FC)大鼠模型结肠上的表达及其与结肠Cajal间质细胞(interstitial cells of Cajal,ICCs)细胞之间的关系,探讨HCN1,HCN2对FC发病的影响。方法:用复方地芬诺酯制造FC大鼠模型,利用...