AEG-1、DLL4在子宫内膜癌中的表达及临床病理相关性的研究  

AEG - 1 ,DLL4 expression in endometrial carcinoma and clinical significance

作　　者：刘运铎[1] 孟凡玲[1] 徐冶[1] 杨萌[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院妇科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2013年第3期223-228,共6页Practical Oncology Journal

基　　金：黑龙江省教育厅科研深题面上项目（12511239）

摘　　要：目的探讨AEG-1、DLL4在子宫内膜癌中的表达及临床病理因素的关系。方法通过免疫组化的方法检测40例正常子宫内膜组织、152例子宫内膜癌中AEG-1、DLL4的蛋白表达水平并观察其表达与子宫内膜癌的临床病理因素之间的相关性。结果在子宫内膜癌中AEG-1、DLIA的阳性表达率要显著高于正常子宫内膜组织（P〈0，01）。其中AEG-1在子宫内膜癌组织中的阳性表达率与患者的年龄和病理类型无统计学意义（P〉O．05），而与组织分级、临床分期、淋巴结转移、肌层浸润有统计学意义（P〈0．05），DLIA在子宫内膜癌组织中的阳性表达率与患者的年龄和病理类型无统计学意义（P〉0．05），而与组织分级、临床分期、淋巴结转移、肌层浸润有统计学意义（P〈0．05）。子宫内膜癌组织的分化程度低、深肌层浸润、分期晚和淋巴结转移者，AEG-1、DLL4阳性表达率高。在子宫内膜癌中，AEG-1、DLL4阳性表达呈显著正相关。结论AEG—1、DLL4在子宫内膜癌的发生、发展中起到重要的作用，可作为判断子宫内膜癌恶性程度、病情进展的重要指标，联合检测用于指导临床诊断有重要的意义。Objective To explore the expressions of AEG - 1 and DLL4 in endometrial carcinoma and detect their clinical significance and pathologic parameters. Methods The expressions of AEG - 1 and DLL4 were measured by immunohistochemical method,including 40 cases with normal endometrium specimens and 152 cases with malignant tumor. The relationship between AEG - 1, DLIA expression and clinicopathological factors was also assessed in these patients. Results The positive expression rate was significantly higher in malignant than that in benign group（P 〈 0.01 ）. The positive expression rate of AEG - 1 was not associated with age and pathologic types （ P 〉 0. 05 ）, but with the clinical stage FIGO stage and metastasis （ P 〈 O. 05 ）. The positive expression rate of AEG - 1 was high in those low differentiation degree, advanced stage and metastasis present cases. Conclusion AEG - 1 and DLIA play a key role in endometrial carcinoma occurrence and development. The expressions of AEG - 1 and DLL4 are. quite helpful in diagnosis and clinicopathologic grade of endometrial carcinoma.

关 键 词：子宫内膜癌 星型胶质瘤上调基因-1 Delta样配体4 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]