塞来昔布和谷氨酰胺保护癌性恶病质肠粘膜屏障机制探讨  

The protection of cancer cachexia mice from intestinal mucosal injury by Celecoxib

作　　者：贾云鹤[1] 李明琦[1] 薛伟男[1] 孙梓程[1] 王轶慧[1] 董巍[1] 王平[1] 朱磊[1] 江志伟[2] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院结直肠外科,哈尔滨150081 [2]南京军区南京总医院解放军普通外科研究所

出　　处：《实用肿瘤学杂志》2013年第3期246-250,共5页Practical Oncology Journal

基　　金：黑龙江省青年基金资助项目（QC08C92）;哈尔滨市科技创新人才研究专项资金项目（2008RFQXS097）

摘　　要：目的探讨塞来昔布和谷氨酰胺保护癌性恶病质小鼠肠粘膜的机制。方法28只恶病质小鼠模型随机分为四组：荷瘤组、塞来昔布、谷氨酰胺组和塞来昔布联合谷氨酰胺组。评价塞来昔布和谷氨酰胺对恶病质鼠体重变化和小肠粘膜萎缩以及血清和小肠组织炎性细胞因子表达的影响。结果塞来昔布和谷氨酰胺均具有抑制恶病质体重下降，保护小肠绒毛，抑制血清中TNFα和IL-6升高、增加sTNFRⅠ、IL-10分泌的作用。二者联用能够升高小肠组织中INF-γ。结论塞来昔布和谷氨酰胺通过调节血清和小肠组织中的炎性反应因子保护肠粘膜，缓解体重下降。Objective To discuss the protection mechanism of intestinal mucosal injury by Cdecoxib and glutamine of cancer cachexia mice. Methods 28 mice were divided into four groups randomly. The weight loss, the height and width of intestinal villi as well as the thickness of muscular layer and basal layer were com- pared in these groups. The inflammatory cytokines in the mucous membrane and blood serum were tested. Results The body weight loss and mucous membrane of small intestine atrophy were inhibited by Celecoxib and glutamine. TNF and IL - 6 expressions decreased, and sTNFR I and IL - 10 expressions increased in blood serum. INFγ lerel increased in mucous membrane after treated by the Ccleeoxib and glutamine. Conclusion Celecoxib and glutamine can protect the weight loss by inhibiting the inflammation in cancer cachexia mice.

关 键 词：癌性恶病质 肠粘膜 细胞因子 塞来昔布 谷氨酰胺 

分 类 号：R735[医药卫生—肿瘤]