血清基质蛋白酶9白介素18在急性脑梗死患者的表达及与预后的关系  

Expressions of MMP-9 and IL-18 in patients with acute cerebral and their relationship with prognosis

作　　者：李慧明[1] 

机构地区：[1]广东深圳市龙岗中心医院神经内科,深圳518172

出　　处：《中国实用神经疾病杂志》2013年第11期13-15,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血清基质蛋白酶9(MMP-9)及白介素18(IL-18)在急性脑梗死患者的表达及与预后的关系。方法选择126例急性脑梗死患者为研究对象(观察组),选择同期体检的80例健康者为对照组。比较2组患者血清MMP-9、IL-18水平及与观察组患者病情严重程度的关系。结果观察组血清MMP-9及IL-18水平显著高于对照组(P<0.05);观察组轻型、中型及重型患者血清MMP-9及IL-18水平依次升高(P<0.05);Logistic回归分析结果显示,MMP-9及IL-18水平与脑梗死患者NIHSS评分显著相关(P<0.05)。结论急性脑梗死血清MMP-9及IL-18水平显著升高,且与患者病情严重程度相关,提示炎症反应在急性脑梗死发病机制中发挥重要作用。Objective To explore the expression of MMP-9 and IL-18 in patients with acute cerebral and their relationship with prognosis.Methods Totally 126 cases with acute cerebral were selected as experience group and 80 healthy persons as control group.MMP-9 and IL-18 between two groups were compared and their relationships with disease severity were analyzed.Results Serum MMP-9 and IL-18 in experience group were significantly higher than those in control group（P0.05）.In patients with mild,moderate and severe neural function defect,serum MMP-9 and IL-18 level gradually increased（P 0.05）.Logistic regression analysis showed that MMP-9 and IL-18 were significantly correlated with NIHSS（P0.05）.Conclusion Serum MMP-9 and IL-18 greatly increase in acute cerebral patients,and have close correlation with disease severity.The results suggest that inflammatory response plays an important role in the pathogenesis of acute cerebral.

关 键 词：急性脑梗死 基质蛋白酶9 白介素18 

分 类 号：R743.33[医药卫生—神经病学与精神病学]