降甲基齐墩果烷型三萜类化合物的研究进展  

Progress on the nor-oleanane triterpenoids

作　　者：徐伟[1] 郑晓红[1] 孟大利[1] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2013年第6期478-483,共6页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金资助项目(81073154)

摘　　要：目的研究降甲基齐墩果烷型三萜类化合物,为其特定生物活性寻找先导化合物。方法根据近10年来的24篇有关降甲基齐墩果烷型三萜类化合物的相关文献报道并结合本课题组的研究工作对降甲基齐墩果烷型三萜类化合物进行阐述。结果分析各种降甲基齐墩果烷型三萜的母核,总结其在自然界的分布、药理活性、波谱学特征,并对C 20(29)末端双键的降甲基齐墩果烷型三萜的生合成来源作以介绍。结论全面系统的评价该类型化合物为获得特定生物活性的先导化合物提供参考依据。Objective To study the nor-oleanane triterpenoids and search the lead compounds to determine its specific bioavailability.Methods According to the related literatures of nor-oleanane triterpenoids and the investigation of our team,the characters of nor-oleanane triterpenoids were illustrated.Results All kinds of the aglycones of the nor-oleanane triterpenoids were analyzed,and their distribution in nature,pharmacological activity,structural diversity and the rules of spectrosocopy were summarized.The biosynthesis pathway of the 28-nor-oleanane triterpene saponins with double bond at C20（29） was introduced.Conclusions This article evaluates the nor-oleanane triterpenoids comprehensively,and provides the reference for searching the lead compounds with bioavailability.

关 键 词：降甲基齐墩果烷型三萜 化学结构特征 NMR规律 

分 类 号：R914[医药卫生—药物化学]