帕金森病发病机制研究  

Study on the pathogenesis of Parkinson’s disease

作　　者：张庆云[1] 董晓东[1] 郝媛[1] 陈玉敏[1] 

机构地区：[1]河北大学基础医学院,河北保定071000

出　　处：《医学研究与教育》2013年第3期85-88,99,共5页Medical Research and Education

基　　金：河北省自然科学基金资助项目(B2011201101);河北大学医工交叉研究基金资助项目(BM201108);河北大学医学学科专项基金资助项目(2012A1003);河北大学大学生创新创业训练项目(2012085);保定市科学技术研究与发展计划项目(08ZF0034)

摘　　要：帕金森病是一种中、老年中枢神经系统退行性疾病,发病机制尚未明确。目前较认可的有遗传因素、环境因素、蛋白质表达异常、氧化应激、铁代谢异常、泛素-蛋白酶体系统及自噬等因素。现就以上几方面对近几年有关帕金森病发病机制的研究作一综述。Parkinson＇s disease （PD） is a common neurodegenerative disease in the central nervous system of middle and old aged people, of which the pathogenesis remains unclear so far. The possible factors are genetics factors, environmental factors, abnormal expression of protein, oxidative stress, abnormal metabolism of iron, the ubiquitin-proteasome system and autophagy. In this article the influencing factors based on several aspects mentioned above on the pathogenesis of Parkinson＇s disease in recent years are reviewed.

关 键 词：帕金森病 发病机制 神经退行性疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]