难治性与一般性抑郁症患者失匹性负波MMN的对比研究  

Comparative study on the mismatch negativity MMN between treatment-resistant depression and general depression

作　　者：邓自和[1] 陈玖[1] 杨来启[1] 吴兴曲[1] 马文涛[1] 刘光雄[1] 贾婷[1] 张彦[1] 

机构地区：[1]中国人民解放军第三医院全军精神疾病防治中心,宝鸡721004

出　　处：《山西医科大学学报》2013年第6期443-445,共3页Journal of Shanxi Medical University

基　　金：军队中医药科研专项课题基金资助项目(10ZYX108);2012兰州军区医药卫生科研计划资助项目(CLZ12JB23)

摘　　要：目的探讨难治性与一般性抑郁症患者失匹性负波MMN的变化差异。方法对24例难治性抑郁症患者(难治组)、25例一般性抑郁症患者(非难治组)进行事件相关电位MMN检查,与24名健康志愿者(对照组)的结果进行比较。结果与对照组相比,难治组、非难治组潜伏期均显著延迟(P<0.05),波幅均显著降低(P<0.01);与非难治组相比,难治组潜伏期显著延迟(P<0.05),波幅差异无统计学意义(P>0.05)。结论抑郁症患者的信息自动加工功能受损,难治性抑郁受损程度大于一般性抑郁症患者。提示MMN变化指标可能是难治性和一般性抑郁患者的共病标记。Abstract： Objective To explore the difference of mismatch negativity MMN between treatment-resistant depression and general depression patients.Methods A total of 24 cases of treatment-resistant depression （TRD group） and 25 cases of general depression （NTRD group） were selected with 24 cases of healthy subjects as control group.The event-related potentials MMN were tested and compared.Results Compared with control group,the patients in treatment-resistant depression group and general depression group had significantly longer latency periods of MMN （P 〈 0.05） and lower amplitudes of MMN （P 〈 0.01）.Compared with general depression group,the latency period of MMN was increased in treatment-resistant depression group （t =2.84,P 〈 0.05）.The amplitude of MMN showed no statistical difference between general depression group and treatment-resistant depression group （P 〉 0.05）.Conclusion Depression patients present a defect on the automatic information processing function,and the extent of damage in patients with treatment-resistant depression is worse than those in general depression patients,which suggests that MMN indicator may be a comorbidity marker between treatment-resistant depression and general depression.

关 键 词：难治性抑郁症 事件相关电位 失匹性负波 

分 类 号：R749.4[医药卫生—神经病学与精神病学]