血管内皮生长因子基因在辽宁绒山羊胎儿期皮肤毛囊发育中表达及其与微血管密度关系的研究  

Study on VEGF in the Expression of Skin Hair Follicle and the Relationship with Microvessel Density by Liaoning Cashmere Goat in Fetal Period

作　　者：谷博[1] 孙丽敏[1] 常青[1] 姜怀志[1] 

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118

出　　处：《中国畜牧兽医》2013年第6期158-161,共4页China Animal Husbandry & Veterinary Medicine

基　　金：国家十一五科技支撑计划项目(2009BADA5B03)

摘　　要：为探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)在辽宁绒山羊胎儿期皮肤毛囊发育中的表达规律及其与皮肤微血管密度(microvessel density,MVD)的关系,采用免疫组化方法对VEGF辽宁绒山羊胎儿期不同阶段的表达及MVD进行检测。结果表明,VEGF在辽宁绒山羊胎儿期75d后的各个时期皮肤毛乳头及毛囊内根鞘上表达,同时随着胎龄的增加,VEGF阳性区域的平均光密度亦随之增加;且皮肤中MVD也随着日龄的增加而逐渐增加,毛囊上的VEGF平均光密度与MVD呈极强正相关(r=0.966,P=0.007)。We used immunohistochemical methods to investigate the expression pattern of vascular endothelial growth fac- tor （VEGF） in hair follicle of Liaoning cashmere goat in fetal period, and detected the expression of VEGF in the different fetal period and microvessel density （MVD）. The research results showed that VEGF expressed in hair papilla and hair follicle inner root sheath in Liaoning cashmere goat of each fetal period after 75 days. At the same time, the average optical density of VEGF-positive area also increased and skin MVD showed a growing trend, and the average optical density and MVD were strong positive correlation （r=0. 966,P=0. 007）.

关 键 词：血管内皮生长因子 微血管密度 胎儿期 辽宁绒山羊 

分 类 号：S827[农业科学—畜牧学]