姜黄素对海马内注射Aβ1-42后大鼠认知功能的影响  

Effect of curcumin on cognitive impairment of rats after hippocampus injected with Aβ1-42

作　　者：隋韵声[1] 宋芷珩[2] 滕伟禹[3] 田力[4] 

机构地区：[1]沈阳市第一人民医院神经内科,辽宁沈阳110041 [2]中国医科大学附属盛京医院神经内科,辽宁沈阳110001 [3]中国医科大学附属第一医院神经内科,辽宁沈阳110001 [4]中国医科大学附属盛京医院老年病科,辽宁沈阳110001

出　　处：《中国现代医学杂志》2013年第10期16-19,共4页China Journal of Modern Medicine

基　　金：辽宁科技计划项目(No:2011020216-406);沈阳市科技项目(No:F10-149-9-56)

摘　　要：目的探讨姜黄素(curcumin)对Aβ1-42诱导的老年痴呆(Alzheimer’s disease,AD)大鼠认知功能的影响及意义。方法将SD大鼠随机分为AD大鼠模型,假手术组及姜黄素组,将Aβ1-42微量注射至大鼠右侧海马,制作AD大鼠模型,一个月后进行定位航行和空间探索水迷宫试验,分别检测大鼠的学习和记忆能力;姜黄素干预组于AD建模后24 h给予300 mg/(kg.d)二甲基亚砜(DMSO)溶解的姜黄素,连续腹腔注射5d;一个月后进行定位航行和空间探索水迷宫试验分别检测各组的学习和记忆能力。结果与假手术组相比,AD模型组大鼠显示学习、记忆能力显著下降(P=0.013);与AD模型组分别对比,姜黄素干预后大鼠空间学习记忆能力明显改善(P=0.021)。结论姜黄素有改善Aβ1-42诱导的AD模型大鼠空间学习记忆障碍的作用。[ Objective ] To investigate the effect and significance of eureumin on cognitive impairment of AD model rats after Aβ1-42 injected into hippocampus. [Methods] The SD rats were divided into three groups： sham group, AD model group and curcumin administrated group. Aβ1-42 was micro-injected into the right hippocampus of rats. 24 h after the injection, Curcumin dissolved with DMSO [300 mg/（kg＇d）] was administrated by intraperitoneal injection to the AD model group for 5 d. One month later, Morris water maze （MWM） was used to study the learning and memory ability in each group every day. [Result] MWM test showed that the rats in AD model group had longer escape latencies compared with those in control group （P =0.013）, and the rats in cureumin group had shorter escape latencies compared with those in model group （P =0.021）. [ Conclusion ] Curcumin can partly improve the spatial learning and memory dysfunction of AD model rats.

关 键 词：姜黄素 淀粉样Β蛋白 认知功能损害 海马 大鼠 

分 类 号：R-332[医药卫生]