伴焦虑、抑郁的正常眼压青光眼患者多导睡眠图分析  

Analysis of polysomnography of normal tension glaucoma patients with anxiety and depression

作　　者：陈杰[1] 仇福成[2] 沈扬[3] 王丽平[3] 张俊[3] 冬雪川[4] 黄萍[4] 张纯[4] 李涛[5] 杜晨[5] 古雅兰[5] 马芙蓉[5] 

机构地区：[1]福州市第一医院神经内科,350009 [2]河北医科大学第一医院神经内科 [3]北京大学第三医院神经内科 [4]北京大学第三医院眼科 [5]北京大学第三医院眼科耳鼻喉科

出　　处：《中华临床医师杂志（电子版）》2013年第9期29-32,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨伴有焦虑、抑郁的正常眼压性青光眼患者多导睡眠图的特点。方法本研究对25例经北京大学第三医院眼科确诊为正常眼压性青光眼的患者,进行汉密尔顿焦虑量表、汉密尔顿抑郁量表、匹兹堡睡眠质量指数、多导睡眠图等检查,其中伴有焦虑和(或)抑郁患者15例(A组),不伴焦虑、抑郁症状患者10例(B组)。结果 (1)两组患者在性别、年龄、青光眼病史长短、吸烟、饮酒、糖尿病、高血压病、心脏病、高脂血症、脑血管病、单纯失眠、失眠并打鼾等方面差异均无统计学意义(P>0.05)。(2)A组匹兹堡睡眠质量指数各指标平均值均高于B组,但两组间差异无统计学意义(P>0.05)。(3)正常眼压性青光眼患者有96%存在多导睡眠图睡眠结构紊乱,与B组相比,A组总睡眠时间明显减少(P<0.05),有效睡眠时间(%)缩短(P<0.05),醒觉时间增加(P<0.05)。结论伴有焦虑、抑郁症状的正常眼压性青光眼患者与不伴有焦虑、抑郁症状的患者相比,更易出现睡眠结构紊乱。多导睡眠图对正常眼压性青光眼患者睡眠结构紊乱的确定提供了可靠的客观依据。Objective To assess the characteristic of normal tension glaucoma patients with anxiety and depression. Methods The study included twenty-five cases of normal tension glaucoma patients who were diagnosed at ophthalmology department of Peking University Third Hospital, by means of the examination with Hamilton anxiety scale, depression scale, Pittsburgh Sleep Quality Index, and polysomnography, among them the patients with anxiety and/or depression syndrome were fifteen cases （Gloup A）, the patients without anxiety and depression symptom were ten cases （ Gloup B）. Results （ 1 ） No significant difference was found between the two groups regarding to sex, age, history of glaucoma length, smoking, drinking, diabetes meilitus, hypertensive disease, heart disease, hyperlipidaemia, cerebrovascular disease, simple insomnia, insomnia and snoring field （ all P 〉 0. 05 ）. （2） For each index of pittsburgh sleep quality index, the Group A scored higher than with the Group B, however,no significant difference was found between the two groups （ P 〉 0. 05 ）. （3） Disorder in polysomnography sleep structure existed in 96% of all normal tension glaucoma patients. Compared with the Group B,the total sleep time in the Group A was less significant（P 〈 0. 05 ）, effective sleep time （ % ）was less （P 〈 0. 05 ）, wakening time was increase （P 〈 0. 05）. Conclusion Compared with the patients without antiety and depression symptom, the normal tension glaucoma patients of antiety and/or depression symptom is more obvious in sleep structure disorder. Polysomnography provided reliable and objective basis in sleep structure disorder of the normal tension glaucoma patients.

关 键 词：青光眼 焦虑 抑郁 睡眠质量 多导睡眠图 

分 类 号：R775[医药卫生—眼科]